RecruitingPhase 2Drug trialPre-operative Targeted Treatments in Molecularly Selected Resectable Colorectal Cancer (UNICORN)This is a window-of-opportunity umbrella platform trial enrolling non-metastatic resectable colorectal patients selected for the presence of a specific targetable molecular alteration. The study aims to test the activity of specific targeted agents/combinations given as a short-course pre-operative strategy, matched with the specific alteration detected, followed by standard of care surgery.