RecruitingPhase 3Drug trialComparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset DiabetesThe primary purpose of this study is to evaluate the efficacy, durability, and mechanism of HbA1c reduction produced by the combination of pioglitazone plus tirzepatide compared to metformin plus sitagliptin in patients with recently diagnosed type 2 diabetes mellitus.