RecruitingPhase 2Drug trialA 20-Week Study Assessing the Efficacy of Apremilast in Patients with EB Simplex GeneralizedThe goal of this clinical trial is to Assessing the Efficacy and Safety of Apremilast in Patients \> 6 years of age with EB simplex generalized . The main question it aims to answer are: describe efficacity of this treatment. Participants will take treatments and have to use bullets during the study period.