RecruitingEarly Phase 1Drug trialConcurrent XRD-0394 With Radiation Therapy for High Grade GliomasThis is an open-label, dose-finding study of XRD-0394 in subjects with newly diagnosed and recurrent high grade gliomas receiving radiation therapy, with and without concurrent temozolomide based on O6-Methylguanine-DNA methyltransferase (MGMT) status for patients with newly diagnosed high grade gliomas.