Recruiting
US Benchmarking Clinical Study
The goal of this observational study is to measure shear wave velocity (SWV) in patients with non-reduced left ventricular ejection fraction (LVEF) heart failure and left ventricular hypertrophy, with or without transthyretin amyloidosis with cardiomyopathy (ATTR-CM), and in control subjects without heart failure or cardiomyopathy.
The main question it aims to answer is:
• Can SWV be used to measure myocardial and liver stiffness in the study's target populations? Researchers will compare patients with ATTR-CM, patients without ATTR-CM, and a control group to determine the distributions of SWV in each population.
Participants will:
* Have a standard cardiology assessment, including a physical exam, blood work, and an echocardiogram.
* Undergo an investigational assessment with the eMyosound LYRA device to measure SWV in their myocardium and liver.
* Have the investigational assessment repeated by a second observer to assess measurement reliability.