RecruitingPhase 1Drug trialDose Escalation Study Evaluating the Safety and Pharmacokinetics of VX-581 in Healthy ParticipantsThe purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of single dose of VX-581 and multiple ascending doses of VX-581 alone and in combination with tezacaftor (TEZ)/deutivacaftor (D-IVA) or D-IVA for up to ten days.