RecruitingPhase 4Drug trialctDNA-guided Addition of Ipilimumab to Patients Receiving Nivolumab and RelatlimabThe purpose of this study is to investigate the use of ctDNA measurements to guide first-lien therapy choice for patients with advanced or metastatic melanoma. Primary endpoints include progression-free survival. Secondary study endpoints include objective response rate and incidence and severity of immune-related adverse events.