Clinical Trials at Cincinnati Children's Hospital Medical Center

As of July 2026, 253 paid clinical trials are recruiting at Cincinnati Children's Hospital Medical Center, located at 3333 BURNET AVENUE, 11027, CINCINNATI, OH 45229, phone (513) 803-4738 in Cincinnati, Ohio. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

View the full facility profile →

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 19, 2026.

Filter results

Filter results

State

City

Facility

Recruitment status

Phase

Study type

Intervention

Condition

Sex

Age

Healthy volunteers only

257 clinical trials at Cincinnati Children's Hospital Medical Center

·Clear filters·↓ Download CSV

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

for Childhood Extracranial Germ Cell Tumor

Sites in Cincinnati, Wilmington +385 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT03067181·Phase 3·Recruiting·Listed Mar 2017

Apply to this trial

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

for Advanced Malignant Solid Neoplasm

Sites in Cincinnati, Franklin +428 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: All ages

Code: NCT05564377·Phase 2·Recruiting·Listed Oct 2022

Apply to this trial

A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab

for Lugano Classification Limited Stage Hodgkin Lymphoma AJCC v8

Drug: Nivolumab

Sites in Cincinnati, Dayton +380 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5 - 60

Code: NCT05675410·Phase 3·Recruiting·Listed Jan 2023

Apply to this trial

A Study to Test the Addition of the Drug Cabozantinib to Chemotherapy in Patients With Newly Diagnosed Osteosarcoma

for High Grade Osteosarcoma

Drug: Cabozantinib

Sites in Cincinnati, Dayton +175 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 40

Code: NCT05691478·Phase 2, Phase 3·Recruiting·Listed Jan 2023

Apply to this trial

Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy

for B Acute Lymphoblastic Leukemia

Sites in Cincinnati, Dayton +186 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 25

Code: NCT03959085·Phase 3·Recruiting·Listed May 2019

Apply to this trial

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

for B Acute Lymphoblastic Leukemia

Sites in Cincinnati, Dayton +139 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 366 Days - 46

Code: NCT06124157·Phase 2·Recruiting·Listed Nov 2023

Apply to this trial

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

for Acute Myeloid Leukemia

Sites in Cincinnati, Dayton +169 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 21

Code: NCT04293562·Phase 3·Recruiting·Listed Mar 2020

Apply to this trial

TIDES 2.0: Prevalence and Longitudinal Course of Depression, Anxiety, and Behavior Problems in Children With Cystic Fibrosis Under 12 Years of Age

for Cystic Fibrosis (CF)

Sites in Cincinnati +11 more locations

Sponsor: State University of New York at Buffalo

Sex: All·Age: 18 Months - 11

Code: NCT07048574·Recruiting·Listed Jul 2025

Apply to this trial

The Pediatric Acute Leukemia (PedAL) Screening Trial - A Study to Test Bone Marrow and Blood in Children With Leukemia That Has Come Back After Treatment or Is Difficult to Treat - A Leukemia & Lymphoma Society and Children's Oncology Group Study

for Acute Lymphoblastic Leukemia

Sites in Cincinnati, Dayton +154 more locations

Sponsor: PedAL BCU, LLC

Sex: All·Age: Up to 22

Code: NCT04726241·Phase 1, Phase 2·Recruiting·Listed Jan 2021

Apply to this trial

I-DECIDE After Bronchiolitis Hospitalization

for Bronchiolitis Acute

Sites in Cincinnati, Dayton +54 more locations

Sponsor: Seattle Children's Hospital

Sex: All·Age: 0 Months - 24 Months

Code: NCT07243652·Recruiting·Listed Nov 2025

Apply to this trial

A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for Down Syndrome

Drug: Nivolumab

Sites in Cincinnati, Dayton +148 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 30

Code: NCT04546399·Phase 2·Recruiting·Listed Sep 2020

Apply to this trial

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

for Ganglioneuroblastoma, Nodular

Sites in Cincinnati, Dayton +151 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 30

Code: NCT06172296·Phase 3·Recruiting·Listed Dec 2023

Apply to this trial

Survivors Journey+

for Pediatric Brain Tumor

Sites in Cincinnati & Columbus

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: 15 - 25

Code: NCT07321353·Recruiting·Listed Jan 2026

Apply to this trial

A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade Glioma

for Low Grade Astrocytoma

Drug: Selumetinib

Sites in Cincinnati, Dayton +115 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 2 - 21

Code: NCT04166409·Phase 3·Recruiting·Listed Nov 2019

Apply to this trial

Inotuzumab Ozogamicin in Treating Younger Patients With B-Lymphoblastic Lymphoma or Relapsed or Refractory CD22 Positive B Acute Lymphoblastic Leukemia

for Recurrent B Acute Lymphoblastic Leukemia

Sites in Cincinnati, Dayton +133 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 1 - 21

Code: NCT02981628·Phase 2·Recruiting·Listed Dec 2016

Apply to this trial

Study to Evaluate Biological & Clinical Effects of Significantly Corrected CFTR Function in Infants & Young Children

for Cystic Fibrosis

Sites in Cincinnati, Columbus +33 more locations

Sponsor: Sonya Heltshe

Sex: All·Age: Up to 10

Code: NCT04509050·Recruiting·Listed Aug 2020

Apply to this trial

A Study Using Nivolumab, in Combination With Chemotherapy Drugs to Treat Nasopharyngeal Carcinoma (NPC)

for Stage II Nasopharyngeal Carcinoma AJCC v8

Drug: Nivolumab

Sites in Cincinnati, Dayton +73 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 21

Code: NCT06064097·Phase 2·Recruiting·Listed Oct 2023

Apply to this trial

A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing Loss

for Childhood Medulloblastoma

Sites in Cincinnati, Dayton +99 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 4 - 21

Code: NCT05382338·Phase 3·Recruiting·Listed May 2022

Apply to this trial

Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia

for Acute Leukemia of Ambiguous Lineage

Drug: Venetoclax

Sites in Cincinnati, Dayton +110 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: Up to 365 Days

Code: NCT06317662·Phase 2·Recruiting·Listed Mar 2024

Apply to this trial

Standardizing Treatments for Pulmonary Exacerbations - Aminoglycoside Study

for Cystic Fibrosis

Sites in Cincinnati, Dayton +57 more locations

Sponsor: Chris Goss

Sex: All·Age: 6+

Code: NCT05548283·Phase 4·Recruiting·Listed Sep 2022

Apply to this trial

A Study of the Drug Selinexor With Radiation Therapy in Patients With Newly-Diagnosed Diffuse Intrinsic Pontine (DIPG) Glioma and High-Grade Glioma (HGG)

for Malignant Glioma

Drug: Selinexor

Sites in Cincinnati, Dayton +106 more locations

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 12 Months - 21

Code: NCT05099003·Phase 1, Phase 2·Recruiting·Listed Oct 2021

Apply to this trial

Milrinone for Prevention of Post-ligation Cardiac Syndrome Trial

for Post-ligation Cardiac Syndrome

Sites in Cincinnati, Cleveland +17 more locations

Sponsor: NICHD Neonatal Research Network

Sex: All·Age: Up to 3 Months

Code: NCT06679855·Phase 3·Recruiting·Listed Nov 2024

Apply to this trial

Rett Syndrome Registry

for Rett Syndrome

Sites in Cincinnati, Columbus +17 more locations

Sponsor: International Rett Syndrome Foundation

Sex: All·Age: 0 - 99

Code: NCT05432349·Recruiting·Listed Jun 2022

Apply to this trial

Multisite Inventory of Neonatal-Perinatal Interventions (MINI) Minimum Dataset

for Infant, Extremely Premature

Sites in Cincinnati, Columbus +41 more locations

Sponsor: The University of Texas Health Science Center, Houston

Sex: All·Age: 0 - 1

Code: NCT05685745·Recruiting·Listed Jan 2023

Apply to this trial

Prevention of Bleeding in Patients With Moderate and Severe Hemophilia A Playing Sports: A Comparison Between Factor VIII and Emicizumab Prophylaxis

for Hemophilia A

Sites in Cincinnati +9 more locations

Sponsor: Wayne State University

Sex: All·Age: 6 - 19

Code: NCT05022459·Recruiting·Listed Aug 2021

Apply to this trial

Project: Every Child for Younger Patients With Cancer

for Adrenal Gland Pheochromocytoma

Sites in Cincinnati, Dayton +231 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 25

Code: NCT02402244·Recruiting·Listed Mar 2015

Apply to this trial

Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

for Cystic Fibrosis

Sites in Cincinnati +30 more locations

Sponsor: University of Washington, the Collaborative Health Studies Coordinating Center

Sex: All·Age: 3 - 18

Code: NCT06654752·Recruiting·Listed Oct 2024

Apply to this trial

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

for Anaplastic Kidney Wilms Tumor

Sites in Cincinnati, Dayton +169 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT04322318·Phase 2·Recruiting·Listed Mar 2020

Apply to this trial

A Prospective Database of Infants With Cholestasis

for Biliary Atresia

Sites in Cincinnati +8 more locations

Sponsor: Arbor Research Collaborative for Health

Sex: All·Age: Up to 6 Months

Code: NCT00061828·Recruiting·Listed Jun 2003

Apply to this trial

Thoracotomy Versus Thoracoscopic Management of Pulmonary Metastases in Patients With Osteosarcoma

for Metastatic Malignant Neoplasm in the Lung

Sites in Cincinnati, Dayton +209 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 50

Code: NCT05235165·Phase 3·Recruiting·Listed Feb 2022

Apply to this trial

Prevention of Graft Rejection in Hematopoietic Stem Cell Transplant (HSCT) Recipients

for Hematopoietic Stem Cell Transplantation

1 location in Cincinnati

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: All ages

Code: NCT07244419·EARLY_Phase 1·Recruiting·Listed Nov 2025

Apply to this trial

A Study Using Risk Factors to Determine Treatment for Children With Favorable Histology Wilms Tumors (FHWT)

for Stage I Mixed Cell Type Kidney Wilms Tumor

Sites in Cincinnati, Dayton +144 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT06401330·Phase 3·Recruiting·Listed May 2024

Apply to this trial

Simulation Trial of Telemedical Support for Paramedics

for Emergencies

Sites in Cincinnati +7 more locations

Sponsor: Boston Medical Center

Sex: All·Age: 21+

Code: NCT06441760·Recruiting·Listed Jun 2024

Apply to this trial

Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion

for High Grade Glioma

Sites in Cincinnati, Columbus +8 more locations

Sponsor: Nationwide Children's Hospital

Sex: All·Age: 1 - 21·Accepts healthy volunteers

Code: NCT06333899·EARLY_Phase 1·Recruiting·Listed Mar 2024

Apply to this trial

Clinical, Imaging, and Endoscopic Outcomes of Children Newly Diagnosed With Crohn's Disease

for Crohn Disease

Sites in Cincinnati, Columbus +19 more locations

Sponsor: Connecticut Children's Medical Center

Sex: All·Age: 6 - 17

Code: NCT05781152·Phase 4·Recruiting·Listed Mar 2023

Apply to this trial

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT

for Central Nervous System Nongerminomatous Germ Cell Tumor

Sites in Cincinnati, Dayton +132 more locations

Sponsor: Children's Oncology Group

Sex: All·Age: 3 - 29

Code: NCT04684368·Phase 2·Recruiting·Listed Dec 2020

Apply to this trial

Outcomes in Pediatric and Young Adult B-Cell Malignancies After Commercially Available Immunotherapy

for Lymphoid Leukemia

Sites in Cincinnati +21 more locations

Sponsor: Stanford University

Sex: All·Age: Up to 26

Code: NCT05865301·Recruiting·Listed May 2023

Apply to this trial

TSC Biosample Repository and Natural History Database

for Tuberous Sclerosis

Sites in Cincinnati, Cleveland +21 more locations

Sponsor: National Tuberous Sclerosis Association

Sex: All·Age: All ages

Code: NCT05676099·Recruiting·Listed Jan 2023

Apply to this trial

TRANSPIRE: Lung Injury in a Longitudinal Cohort of Pediatric HSCT Patients

for Hematopoietic Stem Cell Transplant (HSCT)

Sites in Cincinnati +8 more locations

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: Up to 24

Code: NCT04098445·Recruiting·Listed Sep 2019

Apply to this trial

NANT 2021-01 Phase II STING (Sequential Temozolomide, Irinotecan, NK Cells and GD2 mAb) Trial

for Neuroblastoma

Drug: Irinotecan

Sites in Cincinnati, Columbus +11 more locations

Sponsor: New Approaches to Neuroblastoma Therapy Consortium

Sex: All·Age: 1 - 31

Code: NCT06450041·Phase 2·Recruiting·Listed Jun 2024

Apply to this trial