ALS — Trials, FDA Actions & Pivotal Research

20 active ALS trials currently recruiting in the US, sourced from ClinicalTrials.gov.

Synced daily from openFDA and ClinicalTrials.gov. Last sync: August 19, 2026.

Find recruiting ALS (amyotrophic lateral sclerosis) trials near you

Recruiting trials by city

Cities where ALS trials in our archive had recruiting sites. Each link lists every currently recruiting paid clinical trial at that location.

Birmingham, AL Boston, MA Fort Lauderdale, FL Jacksonville, FL Miami, FL Sacramento, CA La Jolla, CA Loma Linda, CA San Francisco, CA Chicago, IL Gainesville, FL Irvine, CA

Active ALS trials

Currently recruiting US trials matching ALS, sourced live from ClinicalTrials.gov. We’ll add per-event articles here as those trials post results or hit primary completion.

Study to Investigate the Safety of the Transplantation (by Injection) of Human Glial Restricted Progenitor Cells (hGRPs; Q-Cells®) Into Subjects With Amyotrophic Lateral Sclerosis (ALS)

for Amyotrophic Lateral Sclerosis

Sponsor: Q Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT02478450·Phase 1, Phase 2·Not Yet Recruiting·Listed Jun 2015

iBCI Optimization for Veterans With Paralysis

for Spinal Cord Injury

1 location in Providence

Sponsor: VA Office of Research and Development

Sex: All·Age: 18 - 80

Code: NCT05470478·Not Yet Recruiting·Listed Jul 2022

Study of [11C]CPPC as a Clinical PET Radioligand Biomarker of Microglial Activation in ALS

for ALS

Sponsor: Johns Hopkins University

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05602142·Phase 1, Phase 2·Not Yet Recruiting·Listed Nov 2022

Digital Speech Markers for Monitoring ALS in Spanish Speakers

for Amyotrophic Lateral Sclerosis

1 location in Fort Lauderdale

Sponsor: Nova Southeastern University

Sex: All·Age: 18 - 90·Accepts healthy volunteers

Code: NCT07341334·Not Yet Recruiting·Listed Jan 2026

Healey ALS MyMatch Common Screening Protocol

for ALS

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT07400393·Not Yet Recruiting·Listed Feb 2026

FUNCtion ALS: Aiming to Restore UNC13A Function in People Living With ALS

for Amyotrophic Lateral Sclerosis

Sponsor: Trace Neuroscience, Inc.

Sex: All·Age: 18 - 75

Code: NCT07674667·Phase 1, Phase 2·Recruiting·Listed Jun 29, 2026

Apply to this trial

Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis

1 location in Iowa City

Sponsor: University of Iowa

Sex: All·Age: 18 - 80

Code: NCT07224269·EARLY_Phase 1·Recruiting·Listed Nov 2025

Apply to this trial

The BANYAN Trial, an ALS MyMatch Trial Evaluating Safety, Biomarker Activity, and Microglial Activation of Nasal Foralumab

for ALS (Amyotrophic Lateral Sclerosis)

Sponsor: Tiziana Life Sciences LTD

Sex: All·Age: 18 - 75

Code: NCT07688239·Phase 2·Not Yet Recruiting·Listed Jul 7, 2026

Therapeutic Approach of Repeated Transient Blood-brain Barrier Opening in Amyotrophic Lateral Sclerosis.

for Amyotrophic Lateral Sclerosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18 - 80

Code: NCT07571486·Phase 1, Phase 2·Recruiting·Listed May 2026

Apply to this trial

Evaluation of the Impact of Virtual Park on Training Motivation in Adult Patients

for Post-stroke

Sponsor: Marta Mondellini

Sex: All·Age: 18+

Code: NCT07616050·Not Yet Recruiting·Listed May 2026

Auto-calibrating System for Upper Limb Disability Assessment, Neurological and Occupational Rehabilitation

for Stroke

Sponsor: University of Pavia

Sex: All·Age: 18 - 80

Code: NCT07636538·Not Yet Recruiting·Listed Jun 2026

Alter-Ego as an Assistive Robotic Device.

for Amyotrophic Lateral Sclerosis

Sponsor: University of Pisa

Sex: All·Age: 18 - 80

Code: NCT07572838·Not Yet Recruiting·Listed May 2026

A Substudy of LY4256984 in Participants With Sporadic Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07571174·Phase 1·Recruiting·Listed May 2026

Apply to this trial

A Master Protocol (OLMP): A Study of LY4256984 in Participants With Amyotrophic Lateral Sclerosis (ALS)

for Amyotrophic Lateral Sclerosis

Sponsor: Eli Lilly and Company

Sex: All·Age: 18 - 80

Code: NCT07571200·Phase 1·Recruiting·Listed May 2026

Apply to this trial

TP04HN106 in the Treatment of Patients With Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis

Sponsor: Talengen Institute of Life Sciences, Shenzhen, P.R. China.

Sex: All·Age: 18+

Code: NCT06726577·Phase 1, Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Research of Traditional Chinese Medicine Oral Preparation of C. Cicadae in the Treatment of ALS Patients With Elevated Plasma Sphingolipids

for Amyotrophic Lateral Sclerosis

Sponsor: The Third Xiangya Hospital of Central South University

Sex: All·Age: 18 - 80

Code: NCT07467746·Phase 2·Not Yet Recruiting·Listed Mar 2026

INdependence Through Endovascular Neuroprosthetic Technology (INTENT): an Early Feasibility Study

for Neurological Disorder

5 locations incl. Jacksonville

Sponsor: Synchron, Inc.

Sex: All·Age: 22+

Code: NCT07543367·Recruiting·Listed Apr 2026

Apply to this trial

A Study of LTX-002 in Adult Participants With Amyotrophic Lateral Sclerosis

for Amyotrophic Lateral Sclerosis

Sponsor: Leal Therapeutics, Inc

Sex: All·Age: 18 - 75

Code: NCT07660614·Phase 1, Phase 2·Recruiting·Listed Jun 2026

Apply to this trial

A Study to Evaluate the Safety, Efficacy, and Pharmacodynamics of PLL001 in ALS Patients

for Amyotrophic Lateral Sclerosis

Sponsor: PLL TX AUSTRALIA PTY LTD

Sex: All·Age: 18 - 75

Code: NCT06513546·Phase 1, Phase 2·Not Yet Recruiting·Listed Jul 2024

Metagenomic Characterization of the Intestinal Microbiota in ALS Patients and Association With Clinical Phenotypes

for Amyotrophic Lateral Sclerosis

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT06771414·Not Yet Recruiting·Listed Jan 2025