Epilepsy — Trials, FDA Actions & Pivotal Research

20 active Epilepsy trials currently recruiting in the US, sourced from ClinicalTrials.gov.

Synced daily from openFDA and ClinicalTrials.gov. Last sync: August 19, 2026.

Find recruiting Epilepsy trials near you

Recruiting trials by city

Cities where Epilepsy trials in our archive had recruiting sites. Each link lists every currently recruiting paid clinical trial at that location.

Boston, MA San Francisco, CA Palo Alto, CA Cleveland, OH Birmingham, AL Jacksonville, FL Miami, FL Sacramento, CA Stanford, CA Worcester, MA Ann Arbor, MI Boise, ID

Active Epilepsy trials

Currently recruiting US trials matching Epilepsy, sourced live from ClinicalTrials.gov. We’ll add per-event articles here as those trials post results or hit primary completion.

Electrophysiologic Mechanisms of Ketamine Antidepressant Response

for Epilepsy

1 location in Atlanta

Sponsor: Emory University

Sex: All·Age: 18+

Code: NCT07768618·Phase 2·Not Yet Recruiting·Listed Aug 17, 2026

Acute Stimulation and Modulation of Stereotyped High-Frequency Oscillations

for Epilepsy

2 locations incl. Rochester

Sponsor: Mayo Clinic

Sex: All·Age: 3 - 70

Code: NCT06898138·Not Yet Recruiting·Listed Mar 2025

Cholinergic Enhancement of Theta

for Epilepsy

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT07228338·EARLY_Phase 1·Not Yet Recruiting·Listed Nov 2025

Human Cognition During Surgery: Stimulation-based and Cholinergic Modulation

for Epilepsy

1 location in Dallas

Sponsor: University of Texas Southwestern Medical Center

Sex: All·Age: 18 - 70

Code: NCT07721272·EARLY_Phase 1·Not Yet Recruiting·Listed Jul 23, 2026

Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome

for Lennox Gastaut Syndrome (LGS)

Sponsor: University of Minnesota

Sex: All·Age: 18 - 65

Code: NCT07568860·Not Yet Recruiting·Listed May 2026

Neural Basis of Cognition

for Epilepsy

Sponsor: Duke University

Sex: All·Age: 12+

Code: NCT05132543·Not Yet Recruiting·Listed Nov 2021

Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures

for Seizures

2 locations incl. Winston-Salem

Sponsor: Azurity Pharmaceuticals

Sex: All·Age: 1 Month - 17

Code: NCT06534502·Phase 4·Not Yet Recruiting·Listed Aug 2024

Evaluation of the FYNA Research OPM MEG Device for Locating Epileptic Foci as Part of Pre-surgical Assessment of Epilepsy

for Epilepsy

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 6 - 65

Code: NCT07281222·Not Yet Recruiting·Listed Dec 2025

Assessment of MRI-guided HIFU for Patients With Drug-resistant Focal Epilepsy

for Epilepsy

Sponsor: Assistance Publique - Hôpitaux de Paris

Sex: All·Age: 18+

Code: NCT07591350·Not Yet Recruiting·Listed May 2026

Biomarker Targeted Stimulation for Epileptiform Events

for Epilepsy

Sponsor: Cadence Neuroscience

Sex: Male·Age: 7+

Code: NCT06424977·Not Yet Recruiting·Listed May 2024

Intracranial CArtography of Cortical Contribution to Respiratory Load Compensation in Epilepsy

for Epilepsy

Sponsor: Hospices Civils de Lyon

Sex: All·Age: 18 - 55

Code: NCT07599150·Not Yet Recruiting·Listed May 2026

A Phase 2 Study of the Safety and Efficacy of AV078 in Participants With Tuberous Sclerosis Complex (TSC) Refractory Epilepsy

for Tuberous Sclerosis Complex

Sponsor: Aeovian Pharmaceuticals, Inc.

Sex: All·Age: 12+

Code: NCT07680322·Phase 2·Not Yet Recruiting·Listed Jul 2, 2026

Neural Mechanisms for Stopping Ongoing Speech Production (Study 2)

for Epilepsy

1 location in Pittsburgh

Sponsor: Lingyun Zhao

Sex: All·Age: 8 - 26

Code: NCT07713706·Enrolling By Invitation·Listed Jul 20, 2026

HOBSCOTCH-YOUTH and Young Adults

for Epilepsy

1 location in Lebanon

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 13 - 29

Code: NCT07735715·Not Yet Recruiting·Listed Jul 30, 2026

Lily's Grace Temporal Interference

for Epilepsy

1 location in Madison

Sponsor: University of Wisconsin, Madison

Sex: All·Age: 18 - 75

Code: NCT07520955·Not Yet Recruiting·Listed Apr 2026

Study Evaluating the Efficacy and Safety of RAP-219 in Adult Participants With Focal Seizures

for Focal Seizure

6 locations incl. Bentonville

Sponsor: Rapport Therapeutics Inc.

Sex: All·Age: 18 - 75

Code: NCT07594119·Phase 3·Recruiting·Listed May 2026

Apply to this trial

Sleep, Music, And Research Trial 2.0

for Epilepsy in Children

Sponsor: National Taiwan University Hospital

Sex: All·Age: 18 Months - 9

Code: NCT07696442·Not Yet Recruiting·Listed Jul 10, 2026

Epilepsy Enhanced Care

for Epilepsy

Sponsor: Ente Ospedaliero Cantonale, Bellinzona

Sex: All·Age: 18+

Code: NCT07709481·Not Yet Recruiting·Listed Jul 16, 2026

Outcomes After Planned Discontinuation of AntiSeizure Medication

for Epilepsy

1 location in Ann Arbor

Sponsor: University of Michigan

Sex: All·Age: 18+

Code: NCT07750496·Phase 4·Recruiting·Listed Aug 6, 2026

Apply to this trial

A Phase I Clinical Trial of UX-GIP001 in the Treatment of Drug-Resistant Unilateral Mesial Temporal Lobe Epilepsy

for Epilepsy

Sponsor: Shanghai UniXell Biotechnology Co., Ltd

Sex: All·Age: 18 - 75

Code: NCT07572812·Phase 1·Not Yet Recruiting·Listed May 2026