Clinical Trials at City of Hope

As of July 2026, 123 paid clinical trials are recruiting at City of Hope, located at 1500 DUARTE RD, DUARTE, CA 91010-3012, phone (626) 256-4673 in Duarte, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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124 clinical trials at City of Hope

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A Study of NX-5948 in Adults With Relapsed/Refractory B-cell Malignancies

for Chronic Lymphocytic Leukemia (CLL)

Sites in Duarte, San Francisco +13 more locations

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05131022·Phase 1·Recruiting·Listed Nov 2021

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A Safety, Tolerability, and Efficacy Study of VX-880 in Participants With Type 1 Diabetes

for Diabetes Mellitus, Type 1

Sites in Duarte, San Francisco +9 more locations

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 18 - 65

Code: NCT04786262·Phase 3·Recruiting·Listed Mar 2021

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Evaluate the Safety, Tolerability, Pharmacokinetic Profile, Efficacy of Bl-M11D1

for Relapsed/Refractory Acute Myeloid Leukemia

Sites in Duarte, Los Angeles +16 more locations

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06714591·Phase 1·Recruiting·Listed Dec 2024

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Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

for Ewing Sarcoma

Sites in Duarte, Beverly Hills +16 more locations

Sponsor: Inhibrx Biosciences, Inc

Sex: All·Age: 12 - 85

Code: NCT03715933·Phase 1·Recruiting·Listed Oct 2018

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A Study of Elritercept to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Who Need Regular Blood Transfusions

for Myelodysplastic Syndromes

Sites in Duarte, Glendale +21 more locations

Sponsor: Takeda

Sex: All·Age: 18+

Code: NCT06499285·Phase 3·Recruiting·Listed Jul 2024

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A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

for Candidemia

Sites in Duarte, Los Angeles +21 more locations

Sponsor: Basilea Pharmaceutica

Sex: All·Age: 18+

Code: NCT05421858·Phase 3·Recruiting·Listed Jun 2022

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A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

for Advanced Solid Tumor

Sites in Duarte +12 more locations

Sponsor: Daiichi Sankyo

Sex: All·Age: 18+

Code: NCT06172478·Phase 2·Recruiting·Listed Dec 2023

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A Phase 2 Study of WU-CART-007, an Anti-CD7 Allogeneic CAR-T Cell Therapy in T-Cell Acute Lymphoblastic Leukemia and Lymphoblastic Lymphoma (T-RRex)

for T-cell Acute Lymphoblastic Leukemia

Sites in Duarte, Los Angeles +11 more locations

Sponsor: Wugen, Inc.

Sex: All·Age: 1+

Code: NCT06514794·Phase 2·Recruiting·Listed Jul 2024

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The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

for Lymphoid Malignancies

Sites in Duarte, Whittier +9 more locations

Sponsor: AVM Biotechnology Inc

Sex: All·Age: 12 - 95

Code: NCT04329728·Phase 1, Phase 2·Recruiting·Listed Apr 2020

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Open Label Study to Evaluate BL-M07D1 in HER2 Expressing Malignant Solid Tumors

for Endometrial Cancer

Sites in Duarte, Los Angeles +15 more locations

Sponsor: SystImmune Inc.

Sex: All·Age: 18+

Code: NCT06293898·Phase 1·Recruiting·Listed Mar 2024

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A Study of CBX-250 in Participants With Relapsed or Refractory Myeloid Leukemias

for High-risk Myelodysplastic Syndrome

Sites in Duarte, Palo Alto +9 more locations

Sponsor: Crossbow Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT06994676·Phase 1·Recruiting·Listed May 2025

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Study of ONO-4685 in Patients With Relapsed or Refractory T Cell Lymphoma

for Relapsed or Refractory T Cell Lymphoma

Sites in Duarte, Orange +17 more locations

Sponsor: Ono Pharmaceutical Co., Ltd.

Sex: All·Age: 18+

Code: NCT05079282·Phase 1·Recruiting·Listed Oct 2021

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A Phase 1/3 Study of T-Cell Receptor Engineered Donor T Cells in Subjects Undergoing Allogeneic Peripheral Blood Stem Cell Transplantation (ALLOHA-2)

for AML

Sites in Duarte +20 more locations

Sponsor: TScan Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT05473910·Phase 1·Recruiting·Listed Jul 2022

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A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia

for Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

Sites in Duarte +17 more locations

Sponsor: MeiraGTx, LLC

Sex: All·Age: 18+

Code: NCT05926765·Phase 2·Recruiting·Listed Jul 2023

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A Study of TRK-950 When Used in Combination With Ramucirumab and Paclitaxel in Patients With Gastric Cancer

for Gastric Adenocarcinoma

Sites in Duarte, Santa Monica +12 more locations

Sponsor: Toray Industries, Inc

Sex: All·Age: 18+

Code: NCT06038578·Phase 2·Recruiting·Listed Sep 2023

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A Study to Assess the Dose, Adverse Events, and Change in Disease Activity of Livmoniplimab as an Intravenous (IV) Solution in Combination With Budigalimab as an IV Solution in Adult Participants With Hepatocellular Carcinoma (HCC)

for Hepatocellular Carcinoma

Drug: Livmoniplimab

Sites in Duarte, Orange +10 more locations

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06109272·Phase 2, Phase 3·Recruiting·Listed Oct 2023

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Eganelisib as Monotherapy and in Combination With Cytarabine in Relapsed/Refractory AML

for AML, Adult

Sites in Duarte +10 more locations

Sponsor: Stelexis BioSciences

Sex: All·Age: 18+

Code: NCT06533761·Phase 1·Recruiting·Listed Aug 2024

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A Study of 177Lu-FAP-2286 in Advanced Solid Tumors

for Solid Tumor

Sites in Duarte, Los Angeles +18 more locations

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04939610·Phase 1, Phase 2·Recruiting·Listed Jun 2021

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Study of ORIC-114 in Patients With Advanced Solid Tumors Harboring an EGFR or HER2 Alteration

for Solid Tumors

Sites in Duarte, Long Beach +15 more locations

Sponsor: ORIC Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05315700·Phase 1, Phase 2·Recruiting·Listed Apr 2022

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A Study of NX-2127 in Adults With Relapsed/Refractory B-cell Malignancies

for Chronic Lymphocytic Leukemia (CLL)

Sites in Duarte +6 more locations

Sponsor: Nurix Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT04830137·Phase 1·Recruiting·Listed Apr 2021

Apply to this trial

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

for Brain Cancer

Sites in Duarte +15 more locations

Sponsor: Adela, Inc

Sex: All·Age: 40+·Accepts healthy volunteers

Code: NCT05366881·Recruiting·Listed May 2022

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A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers

for Colorectal Cancer

Sites in Duarte +2 more locations

Sponsor: Dispatch Biotherapeutics

Sex: All·Age: 18+

Code: NCT07544589·Phase 1·Recruiting·Listed Apr 2026

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DOC1021 Dendritic Cell Immunotherapy for Refractory Melanoma

for Refractory Melanoma

Sites in Duarte +5 more locations

Sponsor: Diakonos Oncology Corporation

Sex: All·Age: 18+

Code: NCT07288112·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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AB-3028, a Programmable Circuit T Cell Therapy in Patients With Castration Resistant Prostate Cancer (CRPC)

for Metastatic Castration Resistant Prostate Cancer (mCRPC)

Sites in Duarte, Los Angeles +7 more locations

Sponsor: Arsenal Biosciences, Inc.

Sex: Male·Age: 18+

Code: NCT07285694·Phase 1, Phase 2·Recruiting·Listed Dec 2025

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A Study of JNJ-90301900 in Combination With Chemoradiation Therapy in Participants With Locally Advanced Head and Neck Squamous Cell Carcinoma

for Squamous Cell Carcinoma of Head and Neck

Sites in Duarte +8 more locations

Sponsor: Johnson & Johnson Enterprise Innovation Inc.

Sex: All·Age: 18 - 74

Code: NCT07219212·Phase 1·Recruiting·Listed Oct 2025

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A Study of JNJ-79635322 in Participants With Relapsed or Refractory Multiple Myeloma or Previously Treated Amyloid Light-chain (AL) Amyloidosis

for Relapsed or Refractory Multiple Myeloma

Sites in Duarte, Irvine +7 more locations

Sponsor: Janssen Research & Development, LLC

Sex: All·Age: 18+

Code: NCT05652335·Phase 1·Recruiting·Listed Dec 2022

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A Trial to Learn if Linvoseltamab is Safe and Works in Adults With Relapsed or Refractory Systemic Light Chain Amyloidosis (AL Amyloidosis)

for Relapsed/Refractory Systemic Light Chain Amyloidosis

Drug: Linvoseltamab

Sites in Duarte +7 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT06292780·Phase 1, Phase 2·Recruiting·Listed Mar 2024

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First-In-Human Study of STX-721/PFL-721 in Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer Harboring EGFR or HER2 Exon 20 Insertion Mutations

for Non-Small Cell Lung Cancer

Sites in Duarte, Huntington Beach +7 more locations

Sponsor: Pierre Fabre Medicament

Sex: All·Age: 18+

Code: NCT06043817·Phase 1, Phase 2·Recruiting·Listed Sep 2023

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A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors

for Urothelial Carcinoma Bladder

Sites in Duarte, Irvine +10 more locations

Sponsor: Aktis Oncology, Inc.

Sex: All·Age: 18+

Code: NCT07020117·Phase 1·Recruiting·Listed Jun 2025

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GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC

for Hepatocellular Carcinoma

Sites in Duarte +4 more locations

Sponsor: Eureka Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT04864054·Phase 1, Phase 2·Recruiting·Listed Apr 2021

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A Study to Evaluate a Novel Gene Therapy in Patients With Relapsed and Refractory Multiple Myeloma

for Multiple Myeloma in Relapse

Sites in Duarte, Palo Alto +5 more locations

Sponsor: Kelonia Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07075185·Phase 1·Recruiting·Listed Jul 2025

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Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease

for Refractory Metastatic Colorectal Cancer

Sites in Duarte, Santa Monica +4 more locations

Sponsor: Delcath Systems Inc.

Sex: All·Age: 18+

Code: NCT06607458·Phase 2·Recruiting·Listed Sep 2024

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A Study of REC-1245 in Participants With Unresectable, Locally Advanced, or Metastatic Cancer

for Unresectable

Sites in Duarte +2 more locations

Sponsor: Recursion Pharmaceuticals Inc.

Sex: All·Age: 12+

Code: NCT06678659·Phase 1, Phase 2·Recruiting·Listed Nov 2024

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A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell Malignancies

for Lymphoma, B-Cell

Sites in Duarte +5 more locations

Sponsor: Umoja Biopharma

Sex: All·Age: 18+

Code: NCT06528301·Phase 1·Recruiting·Listed Jul 2024

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A Phase 1 Study to Evaluate Safety and Efficacy of XER-001 (Amifostine for Nasoduodenal Delivery) in Combination With Sterotactic Body Radiotherapy for Treatment in Patients With Locally Advanced Pancreatic Cancer.

for Locally Advanced Pancreatic Adenocarcinoma

Sites in Duarte, Irvine +2 more locations

Sponsor: Xerient Pharma

Sex: All·Age: 18+

Code: NCT07157033·Phase 1, Phase 2·Recruiting·Listed Sep 2025

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A Trial to Study if REGN5837 in Combination With Odronextamab is Safe for Adult Participants With Aggressive B-cell Non-Hodgkin Lymphomas

for B-cell Non-Hodgkins Lymphoma (B-NHL)

Drug: Odronextamab

Sites in Duarte, Santa Monica +7 more locations

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT05685173·Phase 1·Recruiting·Listed Jan 2023

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Gene Therapy for CD19-Positive Hematologic Malignancies (SENTRY-CD19)

for B-cell Acute Lymphoblastic Leukemia

Sites in Duarte, Los Angeles +7 more locations

Sponsor: Vironexis Biotherapeutics Inc.

Sex: All·Age: 13 - 90

Code: NCT06533579·Phase 1, Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

This is a Phase 1 Study to Evaluate the Safety of LTZ-301 in Patients With Non-Hodgkin Lymphoma

for Non-Hodgkin Lymphoma Refractory/ Relapsed

Sites in Duarte +4 more locations

Sponsor: LTZ Therapeutics, Inc.

Sex: All·Age: 18+

Code: NCT07121946·Phase 1·Recruiting·Listed Aug 2025

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Safety and Immunogenicity of Innocell Autologous Cellular Immunotherapy for Recurrent Epithelial Ovarian Cancer

for Ovarian Cancer

1 location in Duarte

Sponsor: PhotonPharma, Inc.

Sex: Female·Age: 18+

Code: NCT06366490·Phase 1·Recruiting·Listed Apr 2024

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A Dose Randomization Study of Bulumtatug Fuvedotin in TNBC Patients Previously Treated With ADCs

for Triple Negative Breast Cancer

Sites in Duarte, La Jolla +4 more locations

Sponsor: Mabwell (Shanghai) Bioscience Co., Ltd.

Sex: All·Age: 18+

Code: NCT06908928·Phase 1·Recruiting·Listed Apr 2025

Apply to this trial