Clinical Trials at City of Hope Medical Center

As of July 2026, 145 paid clinical trials are recruiting at City of Hope Medical Center, located at 1500 DUARTE RD, DUARTE, CA 91010-3012, phone (800) 826-4673 in Duarte, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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149 clinical trials at City of Hope Medical Center

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Venetoclax and Obinutuzumab Followed by Epcoritamab for the Treatment of Untreated Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma, LonGEVity Trial

for Chronic Lymphocytic Leukemia

Drug: Epcoritamab

Sites in Duarte, Long Beach +5 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07218510·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

Asciminib as Maintenance Treatment After Cellular Therapies for Adults With Philadelphia Chromosome Positive Acute Lymphoblastic Leukemia

for B Acute Lymphoblastic Leukemia With t(9

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07040982·Phase 1·Recruiting·Listed Jun 2025

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Emapalumab With Post-Transplant Cyclophosphamide, Tacrolimus and Mycophenolate Mofetil for the Prevention of Graft-versus-Host Disease After Donor Reduced-Intensity Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75

Code: NCT06996119·Phase 1·Recruiting·Listed May 2025

Apply to this trial

Adding a Live Biotherapeutic Product (CBM588) to Pembrolizumab for the Treatment of Renal Cell Cancer After Surgery

for Clear Cell Renal Cell Carcinoma

Sites in Duarte & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07037004·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

Metformin for the Treatment of Insulin Resistance in Women With Stage I-III Breast Cancer Completing Chemotherapy

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Duarte, Riverside & La Jolla

Sponsor: City of Hope Medical Center

Sex: Female·Age: 18+

Code: NCT06763328·Phase 3·Recruiting·Listed Jan 2025

Apply to this trial

Tagraxofusp and Azacitidine for Maintenance Treatment in Patients With CD123 Positive AML and MDS Following Donor Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75

Code: NCT06498973·Phase 1·Recruiting·Listed Jul 2024

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Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma

for Folliculotropic Mycosis Fungoides

Drug: Durvalumab

Sites in Duarte +3 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT03011814·Phase 1, Phase 2·Recruiting·Listed Jan 2017

Apply to this trial

Loncastuximab Tesirine and Mosunetuzumab for the Treatment of Relapsed or Refractory Diffuse Large B-Cell Lymphoma

for Recurrent Diffuse Large B-Cell Lymphoma

Drug: Mosunetuzumab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05672251·Phase 2·Recruiting·Listed Jan 2023

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Leflunomide in Combination With Steroids for the Treatment of Acute Graft-versus-Host Disease After Donor Stem Cell Transplant for Hematologic Malignancies

for Acute Graft Versus Host Disease

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05443425·Phase 1·Recruiting·Listed Jul 2022

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Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving Chemotherapy Radiation Therapy

for Lung Non-Small Cell Carcinoma

Sites in Duarte +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT06139627·Recruiting·Listed Nov 2023

Apply to this trial

Early Onset Colorectal Cancer Detection

for Colorectal Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 50·Accepts healthy volunteers

Code: NCT06342401·Recruiting·Listed Apr 2024

Apply to this trial

An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer

for Hepatocellular Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06342414·Recruiting·Listed Apr 2024

Apply to this trial

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

for Acute Lymphoblastic Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 80

Code: NCT06815003·Phase 2·Recruiting·Listed Feb 2025

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Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant Astrocytoma

for Recurrent Astrocytoma, IDH-Mutant, Grade 3

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06815029·Phase 1·Recruiting·Listed Feb 2025

Apply to this trial

FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery

for Rectal Adenocarcinoma

Drug: Botensilimab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06780787·Phase 2·Recruiting·Listed Jan 2025

Apply to this trial

Comparing the Impact of Four Types of Meditation Practices for Relaxation in Cancer Survivors

for Hematopoietic and Lymphatic System Neoplasm

Sites in Duarte & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06500377·Recruiting·Listed Jul 2024

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Modified Immune Cells (TAG72-CAR T Cells) for the Treatment of Patients With Platinum Resistant Epithelial Ovarian Cancer

for Platinum-Resistant Ovarian Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Female·Age: 18+

Code: NCT05225363·Phase 1·Recruiting·Listed Feb 2022

Apply to this trial

An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis

for Anatomic Stage IV Breast Cancer AJCC v8

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05376878·Phase 4·Recruiting·Listed May 2022

Apply to this trial

Circulating Biomarkers in the Development of Type 1 Diabetes

for Diabetes

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT05505669·Recruiting·Listed Aug 2022

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8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia

for Acute Myeloid Leukemia

Drug: Venetoclax

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05263284·Phase 1·Recruiting·Listed Mar 2022

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Intracerebroventricular Administration of CD19-CAR T Cells (CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/Mem T-lymphocytes) for the Treatment of Central Nervous System Lymphoma

for Central Nervous System Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05625594·Phase 1·Recruiting·Listed Nov 2022

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Diagnostic DNA Methylation Signature in Diagnosing Thyroid Cancer After Fine-Needle Aspiration in Patients With Thyroid Nodules

for Thyroid Gland Nodule

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 19+

Code: NCT03676647·Recruiting·Listed Sep 2018

Apply to this trial

Leflunomide, Pomalidomide, and Dexamethasone for the Treatment of Relapsed or Refractory Multiple Myeloma

for Recurrent Plasma Cell Myeloma

Sites in Duarte, South Pasadena +6 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04508790·Phase 2·Recruiting·Listed Aug 2020

Apply to this trial

Cemiplimab and Transarterial Radioembolization With Y-90 SIR-S Spheres for the Treatment of Liver Directed Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Drug: Cemiplimab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06860815·Phase 2·Recruiting·Listed Mar 2025

Apply to this trial

Enasidenib (AG-221) Maintenance Post Allogeneic HCT in Patients With IDH2 Mutation

for Acute Myeloid Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT03728335·Phase 2·Recruiting·Listed Nov 2018

Apply to this trial

225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

for Acute Lymphoblastic Leukemia

Drug: Daratumumab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06287944·Phase 1·Recruiting·Listed Mar 2024

Apply to this trial

Haploidentical Transplantation With Pre-Transplant Immunosuppressive Therapy for Patients With Sickle Cell Disease

for Sickle Cell Disease

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 1 - 30

Code: NCT03279094·Phase 1·Recruiting·Listed Sep 2017

Apply to this trial

Metabolic Interventions (Time-Restricted Eating, GLP1 Receptor Agonist, and Heart Healthy Diet) to Improve Cardiometabolic Health in Prostate Cancer Patients During Androgen Deprivation Therapy, IMPACT-ADT Trial

for Prostate Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 30 - 79

Code: NCT07202247·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

Phase II Non-Randomized Study Evaluating POSLUMA-PSMA PET Response After Oligo- Metastatic/Progressive-directed Treatment With Radiotherapy (PROMPT-R)

for Prostate Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT07210086·Phase 2·Recruiting·Listed Oct 2025

Apply to this trial

Abemaciclib and Endocrine Therapy in Older Patients With Breast Cancer.

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Duarte, South Pasadena +4 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 70+

Code: NCT04305834·Phase 2·Recruiting·Listed Mar 2020

Apply to this trial

Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome

for Acute Lymphoblastic Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 60+·Accepts healthy volunteers

Code: NCT06195891·Phase 1·Recruiting·Listed Jan 2024

Apply to this trial

Allogeneic CMV-Specific CD19-CAR T Cells Plus CMV-MVA Triplex Vaccine After Matched Related Donor Hematopoietic Cell Transplant for the Treatment of Patients With High-Risk Acute Lymphoblastic Leukemia

for Acute Lymphoblastic Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06735690·EARLY_Phase 1·Recruiting·Listed Dec 2024

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Zanubrutinib in Combination With Sonrotoclax for the Treatment of Underrepresented Ethnic and Racial Minorities With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma

for Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Drug: Sonrotoclax

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06859008·Phase 1·Recruiting·Listed Mar 2025

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Venetoclax, Lenalidomide and Rituximab in Patients With Previously Untreated Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Venetoclax

Sites in Duarte +3 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT03523975·Phase 1, Phase 2·Recruiting·Listed May 2018

Apply to this trial

Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Duarte +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 65+

Code: NCT06042569·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

Digital Health Intervention for Self-Management and Telemonitoring in Chimeric Antigen Receptor (CAR-T) Therapy

for Hematologic Malignancies

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT07186192·Phase 3·Recruiting·Listed Sep 2025

Apply to this trial

Gemcitabine and Leflunomide in Patients With Advanced Unresectable Pancreatic Cancer

for Advanced Pancreatic Adenocarcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06454383·Phase 1·Recruiting·Listed Jun 2024

Apply to this trial

Dabrafenib, Trametinib, and IMRT in Treating Patients With BRAF Mutated Anaplastic Thyroid Cancer

for BRAF NP_004324.2:p.V600E

Drug: Dabrafenib

Sites in Duarte +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT03975231·Phase 1·Recruiting·Listed Jun 2019

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Mezigdomide (CC-92480) Post Idecabtagene Vicleucel in Treating Patients With Relapsed Multiple Myeloma

for Multiple Myeloma

Drug: Mezigdomide

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06048250·Phase 1·Recruiting·Listed Sep 2023

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Carfilzomib in Combination With Sotorasib for the Treatment of Patients With KRAS G12C Mutated Advanced or Metastatic Non-small Cell Lung Cancer

for Advanced Lung Non-Small Cell Carcinoma

Drug: Sotorasib

Sites in Duarte & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06249282·Phase 1·Recruiting·Listed Feb 2024

Apply to this trial