Clinical Trials at City of Hope Medical Center

As of July 2026, 145 paid clinical trials are recruiting at City of Hope Medical Center, located at 1500 DUARTE RD, DUARTE, CA 91010-3012, phone (800) 826-4673 in Duarte, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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149 clinical trials at City of Hope Medical Center

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CMV-MVA Triplex Vaccination in HLA-Matched Related Stem Cell Donors for the Prevention of CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplant

for Acute Lymphoblastic Leukemia

Sites in Duarte +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT06059391·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

TBI Using IMRT and Cyclophosphamide Prior to Stem Cell Transplant for the Treatment of Severe Systemic Sclerosis

for Systemic Scleroderma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 65

Code: NCT04380831·EARLY_Phase 1·Recruiting·Listed May 2020

Apply to this trial

Fecal Microbiome Transplant to Remodel Intestinal Microbiota for Patients With Relapsed or Refractory Lymphoma With Exposure to High-Risk Antibiotics Who Are Receiving Chimeric Antigen Receptor T Cells

for Recurrent Diffuse Large B-Cell Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07042438·Phase 2·Recruiting·Listed Jun 2025

Apply to this trial

Telephone-based Physical Activity Coaching or Self Monitored Physical Activity to Improve Physical Function in Older Adults Who Are Undergoing Surgery for Lung Cancer and Their Caregivers

for Lung Carcinoma

Sites in Duarte, Upland +14 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06196008·Recruiting·Listed Jan 2024

Apply to this trial

Pacritinib in Combination With a BTK Inhibitor for the Treatment of Patients With Relapsed or Refractory Mantle Cell Lymphoma

for Recurrent Mantle Cell Lymphoma

Drug: Pacritinib

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06675123·Phase 1·Recruiting·Listed Nov 2024

Apply to this trial

Asparaginase Erwinia Chrysanthemi With Chemotherapy for the Treatment of High-Risk Adults With Newly Diagnosed Acute Lymphoblastic Leukemia or Lymphoblastic Lymphoma

for B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative

Sites in Duarte, Los Angeles +6 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 54

Code: NCT06918431·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Nemtabrutinib

Sites in Duarte & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06572618·Phase 2·Recruiting·Listed Aug 2024

Apply to this trial

Risk Assessment Evaluation for Identifying Participants at High Risk for Stomach Cancer

for Gastric Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 40 - 80·Accepts healthy volunteers

Code: NCT06408220·Recruiting·Listed May 2024

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Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

for Acute Leukemia

Drug: Revumenib

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 2+

Code: NCT06575296·Phase 1·Recruiting·Listed Aug 2024

Apply to this trial

Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant

for Acute Myeloid Leukemia

Sites in Duarte +1 more location

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06543381·Phase 1·Recruiting·Listed Aug 2024

Apply to this trial

Telehealth Intervention for Ostomy Self-Management

for Colorectal Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06528990·Phase 2·Recruiting·Listed Jul 2024

Apply to this trial

CAR T Cells After Lymphodepletion for the Treatment of IL13Rα2 Positive Recurrent or Refractory Brain Tumors in Children

for Malignant Brain Neoplasm

Sites in Duarte, Los Angeles +1 more location

Sponsor: City of Hope Medical Center

Sex: All·Age: 4 - 25

Code: NCT04510051·Phase 1·Recruiting·Listed Aug 2020

Apply to this trial

Phase II Trial of Lung Chemoemobolization

for Lung Non-Small Cell Carcinoma

Sites in Duarte +1 more location

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05672108·Phase 2·Recruiting·Listed Jan 2023

Apply to this trial

CD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia

for Acute Myeloid Leukemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05672147·Phase 1·Recruiting·Listed Jan 2023

Apply to this trial

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) for the Treatment of Intermediate or High Grade B-Cell Non-Hodgkin Lymphoma

for High Grade B-Cell Non-Hodgkin's Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05801913·Phase 1·Recruiting·Listed Apr 2023

Apply to this trial

CMV-specific HIV-CAR T Cells as Immunotherapy for HIV/AIDS

for HIV-1

Sites in Duarte & San Diego

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06252402·EARLY_Phase 1·Recruiting·Listed Feb 2024

Apply to this trial

Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes

for Diabetes Mellitus, Type 1

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 68

Code: NCT03746769·Phase 1, Phase 2·Recruiting·Listed Nov 2018

Apply to this trial

Evaluation of DNA Methylation Signatures for the Diagnosis and Management of Thyroid Nodules

for Thyroid Gland Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05229341·Recruiting·Listed Feb 2022

Apply to this trial

Genetically Modified T-cells (CMV-Specific CD19-CAR T-cells) Plus a Vaccine (CMV-MVA Triplex) Following Stem Cell Transplantation for the Treatment of Intermediate or High Grade B-cell Non-Hodgkin Lymphoma

for B-Cell Non-Hodgkin Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05432635·Phase 1·Recruiting·Listed Jun 2022

Apply to this trial

Glofitamab With Obinutuzumab, Venetoclax, and Lenalidomide for the Treatment of Patients With Newly Diagnosed High Risk Mantle Cell Lymphoma

for Blastoid Variant Mantle Cell Lymphoma

Drug: Glofitamab

Sites in Duarte +1 more location

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 80

Code: NCT05861050·Phase 1, Phase 2·Recruiting·Listed May 2023

Apply to this trial

Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

for Recurrent Diffuse Large B-Cell Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05800405·EARLY_Phase 1·Recruiting·Listed Apr 2023

Apply to this trial

Vemurafenib and Cobimetinib for the Treatment of Patients With High Risk Differentiated Thyroid Carcinoma With BRAFV600E Mutation

for Thyroid Gland Follicular Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06440850·Phase 2·Recruiting·Listed Jun 2024

Apply to this trial

Quality of Life in Cutaneous Lymphoma Patients Using the Skindex29

for Cutaneous Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04670874·Recruiting·Listed Dec 2020

Apply to this trial

Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate Cancer

for Castration-Sensitive Prostate Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT04734730·Phase 2·Recruiting·Listed Feb 2021

Apply to this trial

Radiotherapy in Combination With Atezolizumab in Locally Advanced Borderline Resectable or Unresectable Cutaneous SCC

for Locally Advanced Skin Squamous Cell Carcinoma

Drug: Atezolizumab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05085496·Phase 1·Recruiting·Listed Oct 2021

Apply to this trial

Study to Evaluate CD8 PET Imaging as a Marker of Immune Response to Stereotactic Body Radiation Therapy (ELIXR)

for Metastatic Malignant Solid Neoplasm

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05371132·Phase 1·Recruiting·Listed May 2022

Apply to this trial

Effects of White Button Mushroom on Inflammation in Obese Postmenopausal Women at High Risk of Breast Cancer

for Breast Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Female·Age: 21+·Accepts healthy volunteers

Code: NCT04913064·Recruiting·Listed Jun 2021

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A Reduced-Intensity Conditioning Regimen (Cyclophosphamide, Pentostatin, Anti-thymocyte Globulin) Followed by Haploidentical Hematopoietic Stem Cell Transplant for the Treatment of Patients With Refractory or Recurrent Severe Aplastic Anemia

for Recurrent Severe Aplastic Anemia

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: Up to 75·Accepts healthy volunteers

Code: NCT05757310·Phase 1·Recruiting·Listed Mar 2023

Apply to this trial

Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study

for Hematopoietic and Lymphoid System Neoplasm

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT05772130·Recruiting·Listed Mar 2023

Apply to this trial

Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma

for Lung Non-Small Cell Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05830058·Phase 2·Recruiting·Listed Apr 2023

Apply to this trial

Acalabrutinib, Obinutuzumab, and Glofitamab for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

for Mantle Cell Lymphoma

Drug: Glofitamab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06054776·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

Light Therapy and Occupational Therapy Fatigue Management-Based Intervention for Patients With Genitourinary Cancers

for Bladder Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05519878·Recruiting·Listed Aug 2022

Apply to this trial

PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer

for Clinical Stage IV Gastric Cancer AJCC v8

Sites in Duarte +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04329494·Phase 1·Recruiting·Listed Apr 2020

Apply to this trial

Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

for Breast Carcinoma

Sites in Duarte & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06731894·Phase 2·Recruiting·Listed Dec 2024

Apply to this trial

Virtual Reality Interventions for the Improvement of Depression, Anxiety and Pain in Patients With Head and Neck Cancer and Caregivers

for Head and Neck Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06985784·Recruiting·Listed May 2025

Apply to this trial

Photon Craniospinal Irradiation for the Treatment of Leptomeningeal Disease Secondary to Breast Cancer or Non-small Cell Lung Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Duarte & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06910761·Phase 2·Recruiting·Listed Apr 2025

Apply to this trial

Yttrium-90 Labeled Anti-CD25 Monoclonal Antibody Combined With BEAM Chemotherapy Conditioning for the Treatment of Primary Refractory or Relapsed Hodgkin Lymphoma

for Recurrent Hodgkin Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04871607·Phase 2·Recruiting·Listed May 2021

Apply to this trial

Brentuximab Vedotin and Nivolumab for the Treatment of Patients With Relapsed/Refractory Classical Hodgkin Lymphoma

for Relapsed Classic Hodgkin Lymphoma

Drug: Nivolumab

Sites in Duarte +4 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04561206·Phase 2·Recruiting·Listed Sep 2020

Apply to this trial

PSCA-Targeting CAR-T Cells Plus or Minus Radiation for the Treatment of Patients With PSCA+ Metastatic Castration-Resistant Prostate Cancer

for Castration-Resistant Prostate Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT05805371·Phase 1·Recruiting·Listed Apr 2023

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Nab-Paclitaxel PIPAC in Combination With Paclitaxel and Ramucirumab for the Treatment of Stomach Cancer With Peritoneal Metastases

for Clinical Stage IVB Gastric Cancer AJCC v8

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06675136·Phase 1·Recruiting·Listed Nov 2024

Apply to this trial