Clinical Trials at City of Hope Medical Center

As of July 2026, 145 paid clinical trials are recruiting at City of Hope Medical Center, located at 1500 DUARTE RD, DUARTE, CA 91010-3012, phone (800) 826-4673 in Duarte, California. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: July 17, 2026.

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149 clinical trials at City of Hope Medical Center

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Ultra-hypofractionated Whole Breast Irradiation With Lumpectomy Cavity Boost for the Treatment of Stage I-III Breast Cancer

for Anatomic Stage I Breast Cancer AJCC v8

Sites in Duarte, Arcadia +5 more locations

Sponsor: City of Hope Medical Center

Sex: Female·Age: 40+

Code: NCT06954831·Phase 2·Recruiting·Listed May 2025

Apply to this trial

Biospecimen Analysis in Detecting Chemical Concentrations in Patients With Chronic or Infectious Diseases Receiving Meditations

for Chronic Disease

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04160429·Recruiting·Listed Nov 2019

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Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

for Acute Lymphoblastic Leukemia

Drug: Ruxolitinib

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 2 - 22

Code: NCT06128070·Phase 2·Recruiting·Listed Nov 2023

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Radioimmunotherapy (111Indium/225Actinium-DOTA-daratumumab) for the Treatment of Relapsed/Refractory Multiple Myeloma

for Recurrent Plasma Cell Myeloma

Drug: Daratumumab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05363111·Phase 1·Recruiting·Listed May 2022

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Extracorporeal Photopheresis and Mogamulizumab for the Treatment of Erythrodermic Cutaneous T Cell Lymphoma

for Folliculotropic Mycosis Fungoides

Sites in Duarte +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT04930653·Phase 2·Recruiting·Listed Jun 2021

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A Prospective, US-based Study Assessing Mogamulizumab-associated Rash in Patients Diagnosed With Mycosis Fungoides or Sezary Syndrome and Treated With Standard of Care Mogamulizumab

for Recurrent Mycosis Fungoides

Sites in Duarte, Palo Alto +8 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07003100·Recruiting·Listed Jun 2025

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Feasibility of Cell-Free DNA Liquid Biopsy in Screening High-Risk Patients for Lung Cancer

for Lung Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 50 - 80·Accepts healthy volunteers

Code: NCT05384769·Recruiting·Listed May 2022

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Stereotactic Body Radiation Therapy and FES PET/CT Imaging for the Treatment of Oligoprogressive Estrogen Receptor Positive Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Sites in Duarte & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06260033·Phase 2·Recruiting·Listed Feb 2024

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Multi-antigen CMV-Modified Vaccinia Ankara Vaccine in Treating Pediatric Patients With Positive Cytomegalovirus Undergoing Donor Stem Cell Transplant

for Cytomegaloviral Infection

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 1 - 21

Code: NCT03354728·Phase 1, Phase 2·Recruiting·Listed Nov 2017

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Bright White Light Therapy in Reducing Cancer-Related Fatigue and Depression in Advanced Prostate Cancer Patients Undergoing Treatment With ADT Combination Therapy

for Advanced Prostate Carcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 60+

Code: NCT05869682·Phase 2·Recruiting·Listed May 2023

Apply to this trial

Telemedicine for Improvement of Care for Older Adults With Cancer in the Underserved Community, The GAIN-S Trial

for Hematopoietic and Lymphoid System Neoplasm

Sites in Duarte, Upland & Lancaster

Sponsor: City of Hope Medical Center

Sex: All·Age: 65+

Code: NCT06022965·Recruiting·Listed Sep 2023

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Geriatric Assessment Guided Interventions to Accelerate Functional Recovery After CAR-T Therapy for Patients 60 Years and Older With B-cell Non-Hodgkin Lymphoma or Multiple Myeloma, GOCART Study

for B-Cell Non-Hodgkin Lymphoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 60+

Code: NCT06052826·Phase 2·Recruiting·Listed Sep 2023

Apply to this trial

Denosumab for Type 1 Diabetes

for Type 1 Diabetes

Sites in Duarte +2 more locations

Sponsor: City of Hope Medical Center

Sex: All·Age: 18 - 50

Code: NCT06524960·Phase 1, Phase 2·Recruiting·Listed Jul 2024

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Mosunetuzumab and Polatuzumab Vedotin for the Treatment of Patients With Relapsed or Refractory Grade 1-3a Follicular Lymphoma

for Recurrent Grade 1 Follicular Lymphoma

Drug: Polatuzumab Vedotin

Sites in Duarte & Irvine

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06453044·Phase 2·Recruiting·Listed Jun 2024

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Zanubrutinib in Combination With Odronextamab for the Treatment of Patients With Richter's Transformation

for Recurrent Transformed Chronic Lymphocytic Leukemia

Drug: Odronextamab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06735664·Phase 1·Recruiting·Listed Dec 2024

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External Beam Radiation Therapy in Combination With Talquetamab for the Treatment of Multiple Myeloma Patients With Extramedullary Disease

for Extramedullary Disease in Multiple Myeloma

Drug: Talquetamab

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06572605·Phase 1, Phase 2·Recruiting·Listed Aug 2024

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AOH1996 for the Treatment of Refractory Solid Tumors

for Refractory Malignant Solid Neoplasm

Sites in Duarte +1 more location

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05227326·Phase 1·Recruiting·Listed Feb 2022

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Biology-Guided Radiation Therapy for the Treatment of Patients With Bone Metastases

for Metastatic Malignant Neoplasm in the Bone

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06549478·Phase 1·Recruiting·Listed Aug 2024

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Study to Detect Changes in Urinary and Gut Microbiome During Androgen Deprivation Therapy and Radiation Therapy in Patients With Prostate Cancer

for Stage I Prostate Cancer AJCC v7

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: Male·Age: 18+

Code: NCT04775355·Recruiting·Listed Mar 2021

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Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase Inhibitor in Oligoprogressive Oncogenic Positive Non-Small Cell Lung Carcinoma

for Lung Non-Small Cell Carcinoma

Sites in Duarte +1 more location

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06014827·Phase 2·Recruiting·Listed Aug 2023

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Prediction of Neoadjuvant Chemotherapy Response in Pancreatic Cancer

for Pancreatic Ductal Adenocarcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT07226154·Recruiting·Listed Nov 2025

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Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial

for Locally Advanced Rectal Adenocarcinoma

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT06834126·Phase 1·Recruiting·Listed Feb 2025

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Spatiotemporal Stereotactic Body Radiation Therapy for the Treatment of Patients With Polymetastatic Solid Tumors

for Metastatic Malignant Solid Neoplasm

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05733949·Recruiting·Listed Feb 2023

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Exercise Training and NR Supplementation Trial to Improve Fitness in AYA HCT Survivors

for Lymphoblastic Leukemia

Sites in Duarte +2 more locations

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 10 - 30

Code: NCT05194397·Phase 2·Recruiting·Listed Jan 2022

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Actinium 225 Labeled Anti-CEA Antibody (Ac225-DOTA-M5A) for the Treatment of CEA Producing Advanced or Metastatic Cancers

for Advanced Cancer

1 location in Duarte

Sponsor: City of Hope Medical Center

Sex: All·Age: 18+

Code: NCT05204147·Phase 1·Recruiting·Listed Jan 2022

Apply to this trial