Paid Clinical Trials in Illinois

Illinois has 2,971 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 23, 2026.

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2,972 clinical trials

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Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

for Locally Advanced Pancreatic Adenocarcinoma

Drug: Peposertib

44 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04172532·Phase 1, Phase 2·Recruiting

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Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

416 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04402788·Phase 2, Phase 3·Recruiting

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A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

for Acral Lentiginous Melanoma

Drug: Ipilimumab

331 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04511013·Phase 2·Recruiting

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Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation

for Atrial Fibrillation

4 locations incl. Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18 - 100

Code: NCT02347111·Phase 4·Recruiting

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Collection of Samples USOPTIVAL Study

for Colorectal Cancer (CRC)

16 locations incl. Chula Vista

Sponsor: Universal Diagnostics

Sex: All·Age: 45 - 84·Accepts healthy volunteers

Code: NCT04792684·Recruiting

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Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

for Advanced Lung Non-Squamous Non-Small Cell Carcinoma

Drug: Bevacizumab

603 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04181060·Phase 3·Recruiting

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Post-op T-DM1 in HER-2+ Salivary Gland Carcinomas

for Salivary Gland Cancer

13 locations incl. Atlanta

Sponsor: Dana-Farber Cancer Institute

Sex: All·Age: 18+

Code: NCT04620187·Phase 2·Recruiting

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Secukinumab Open Label Roll-over Extension Protocol

for Autoimmunity, Inflammation

Drug: Secukinumab

28 locations incl. Fullerton

Sponsor: Novartis Pharmaceuticals

Sex: All·Age: 6 - 100

Code: NCT04638647·Phase 4·Recruiting

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A Trial to Find Out How Safe REGN7075 is and How Well it Works in Combination With Cemiplimab for Adult Participants With Advanced Cancers

for Advanced Solid Tumors

Drug: Cemiplimab

21 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: 18+

Code: NCT04626635·Phase 1, Phase 2·Recruiting

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Parkinson's Foundation PD GENEration Genetic Registry

for Parkinson's Disease

54 locations incl. Birmingham

Sponsor: Parkinson's Foundation

Sex: All·Age: 18+

Code: NCT04994015·Recruiting

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Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement

for Aortic Stenosis

55 locations incl. Huntsville

Sponsor: University of British Columbia

Sex: All·Age: All ages

Code: NCT04634240·Recruiting

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Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

for Heart Failure With Preserved Ejection Fraction (HFpEF

20 locations incl. Birmingham

Sponsor: Axon Therapies, Inc.

Sex: All·Age: 40+

Code: NCT04592445·Recruiting

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Eosinophilic Gastrointestinal Disorders Registry

for Eosinophilic Esophagitis

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: All·Age: 1 - 25

Code: NCT05199532·Recruiting

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A Study to Compare Blinatumomab Alone to Blinatumomab With Nivolumab in Patients Diagnosed With First Relapse B-Cell Acute Lymphoblastic Leukemia (B-ALL)

for Down Syndrome

Drug: Nivolumab

209 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 1 - 30

Code: NCT04546399·Phase 2·Recruiting

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Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)

for Recurrent World Health Organization (WHO) Grade II Glioma

Drug: Trametinib

17 locations incl. Birmingham

Sponsor: University of California, San Francisco

Sex: All·Age: 1 - 25

Code: NCT04485559·Phase 1·Recruiting

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ROX Index for the Timing of Intubation in Nasal High Flow

for Acute Hypoxemic Respiratory Failure

1 location in Chicago

Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Sex: All·Age: 18 - 120

Code: NCT04707729·Recruiting

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A Randomized Trial to Evaluate Sequential vs Simultaneous Patching

for Amblyopia

68 locations incl. Birmingham

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 3 - 13

Code: NCT04378790·Phase 3·Recruiting

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A Study to Find Out How Safe REGN5668 is and How Well it Works In Adult Women When Given With Either Cemiplimab, or Cemiplimab + Fianlimab, or Ubamatamab

for Ovarian Cancer

Drug: Cemiplimab

13 locations incl. Duarte

Sponsor: Regeneron Pharmaceuticals

Sex: Female·Age: 18+

Code: NCT04590326·Phase 1, Phase 2·Recruiting

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Long-term Efficacy and Safety of OLE LIB003 in HoFH, HeFH, and High-risk CVD Patients Requiring Further LDL-C Reduction

for Cardiovascular Disease With Mention of Arteriosclerosis

4 locations incl. Evanston

Sponsor: LIB Therapeutics LLC

Sex: All·Age: 10+

Code: NCT04798430·Phase 3·Enrolling By Invitation

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

for Advanced Non-Small Cell Lung Cancer

Drug: Adagrasib

220 locations incl. Goodyear

Sponsor: Mirati Therapeutics Inc.

Sex: All·Age: 18+

Code: NCT04613596·Phase 2, Phase 3·Recruiting

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Clinical Decision Support Tool in PARDS Pilot Study

for Ventilation Therapy

6 locations incl. Chicago

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 1 Month - 18

Code: NCT04068012·Recruiting

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Evaluate the Continued Safety and Performance of the Foot and Ankle Products

for Hyperpronated Foot

5 locations incl. Sacramento

Sponsor: Arthrex, Inc.

Sex: All·Age: 2+·Accepts healthy volunteers

Code: NCT04715139·Recruiting

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Comparison of Partial Rotator Cuff Repair vs. Superior Capsular Reconstruction for Irreparable Rotator Cuff Tears

for Rotator Cuff Tears

3 locations incl. Chicago

Sponsor: University Hospitals Cleveland Medical Center

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT04742452·Recruiting

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Adherus™ Dural Sealant in Spinal Procedures

for Spinal Duraplasty

14 locations incl. Duarte

Sponsor: Stryker Craniomaxillofacial

Sex: All·Age: 18 - 75

Code: NCT04498026·Enrolling By Invitation

Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

for Parkinson Disease

12 locations incl. Birmingham

Sponsor: Michael J. Fox Foundation for Parkinson's Research

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT06719583·Recruiting

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The ENCIRCLE Trial

for Mitral Regurgitation

56 locations incl. Huntsville

Sponsor: Edwards Lifesciences

Sex: All·Age: 18+

Code: NCT04153292·Recruiting

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A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

for Non-small Cell Lung Cancer

38 locations incl. Duarte

Sponsor: Genentech, Inc.

Sex: All·Age: 18+

Code: NCT04302025·Phase 2·Recruiting

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The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies

for Lymphoid Malignancies

11 locations incl. Duarte

Sponsor: AVM Biotechnology Inc

Sex: All·Age: 12 - 95

Code: NCT04329728·Phase 1, Phase 2·Recruiting

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Gut Microbiome and Sex as Risk Factors for Kidney Stones After Bariatric Surgery

for Bariatric Surgery Candidate

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 130

Code: NCT04590690·Recruiting

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LymphBridge: Surgical Evaluation for Breast Cancer-Associated Lymphedema (BioBridge)

for Lymphedema

2 locations incl. Chicago

Sponsor: Fibralign Corporation

Sex: All·Age: 18 - 75

Code: NCT04606030·Recruiting

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Abbott Vascular Medical Device Registry

for Acute Myocardial Infarction

7 locations incl. Birmingham

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT04573660·Recruiting

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The MIRROR Registry: Minimally Invasive IntRaceRebral HemORrhage Evacuation

for Supratentorial Hemorrhage

20 locations incl. Burbank

Sponsor: Integra LifeSciences Corporation

Sex: All·Age: 18+

Code: NCT04494295·Recruiting

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Hip Arthroscopy Postoperative Opioid Demands

for Opioid Use

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT04094701·Recruiting

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Long-term Follow-up of Subjects with Sickle Cell Disease Treated with Ex Vivo Gene Therapy

for Sickle Cell Disease

15 locations incl. Birmingham

Sponsor: Genetix Biotherapeutics Inc.

Sex: All·Age: 2 - 53

Code: NCT04628585·Enrolling By Invitation

NEXUS Aortic Arch Clinical Study to Evaluate Safety and Effectiveness

for Aortic Dissection

31 locations incl. Birmingham

Sponsor: Endospan Ltd.

Sex: All·Age: 18+

Code: NCT04471909·Recruiting

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A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

for Anaplastic Kidney Wilms Tumor

177 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: Up to 30

Code: NCT04322318·Phase 2·Recruiting

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Child and Adolescent Registry for Participants With Narcolepsy

for Narcolepsy

25 locations incl. Phoenix

Sponsor: Jazz Pharmaceuticals

Sex: All·Age: Up to 17

Code: NCT04899947·Recruiting

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Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

for Biochemically Recurrent Prostate Carcinoma

Drug: Apalutamide

342 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: Male·Age: 18+

Code: NCT04423211·Phase 3·Recruiting

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Detecting HPV DNA in Anal and Cervical Cancers

for Cervical Cancer

2 locations incl. Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04857528·Recruiting

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Efficacy Of Hiatal Closure For GERD

for Gastro Esophageal Reflux

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18 - 50

Code: NCT06280664·Recruiting

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