Paid Clinical Trials in Illinois

Illinois has 2,972 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 24, 2026.

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2,975 clinical trials

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Gravity Versus Vacuum Based Indwelling Tunneled Pleural Drainage System

for Pleural Effusion

5 locations incl. Arlington Heights

Sponsor: Johns Hopkins University

Sex: All·Age: 18+

Code: NCT03831386·Recruiting

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Characterization of the Microbiome in Cutaneous T Cell Lymphoma

for Cutaneous T Cell Lymphoma

1 location in Chicago

Sponsor: Northwestern University

Sex: All·Age: 18 - 89·Accepts healthy volunteers

Code: NCT03932279·Recruiting

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Studying Health Outcomes After Treatment in Patients With Retinoblastoma

for Retinoblastoma

10 locations incl. Chicago

Sponsor: Vanderbilt-Ingram Cancer Center

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT03932786·Recruiting

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The Informed Genetics Annotated Patient Registry

for Predisposition, Genetic

5 locations incl. Redding

Sponsor: Medneon

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT04419896·Enrolling By Invitation

The ImPreSS Trial: Pharmacogenomic Decision Making at Time of Surgery

for Surgery

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+·Accepts healthy volunteers

Code: NCT03729180·Recruiting

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rTMS Target Identification for Functional Disability in AUD+mTBI

for Alcohol Use Disorder

1 location in Hines

Sponsor: VA Office of Research and Development

Sex: All·Age: 22 - 65

Code: NCT04043442·Phase 2·Enrolling By Invitation

Forceps vs. Snare IVC Filter Removal

for DVT

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT04092192·Recruiting

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Methadone and Quality of Postoperative Recovery

for Quality of Recovery Scores

1 location in Evanston

Sponsor: Endeavor Health

Sex: All·Age: 18 - 90

Code: NCT03168958·Phase 4·Recruiting

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Study of Individuals Affected With Hypoplasminogenemia

for Plasminogen Deficiency

13 locations incl. Birmingham

Sponsor: Indiana Hemophilia &Thrombosis Center, Inc.

Sex: All·Age: All ages

Code: NCT03797495·Recruiting

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Anesthetics and Analgesics in Children

for Anesthesia

11 locations incl. Stanford

Sponsor: Chi Dang Hornik

Sex: All·Age: 0 - 17

Code: NCT03427736·Recruiting

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Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases

for Brain Metastases

73 locations incl. Tucson

Sponsor: Canadian Cancer Trials Group

Sex: All·Age: 18+

Code: NCT03550391·Phase 3·Recruiting

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Lidocaine Infusion in Pancreatic Cancer

for Pancreatic Cancer

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 18+

Code: NCT04048278·EARLY_Phase 1·Recruiting

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Improve Dynamic Lateral Balance of Humans With SCI

for Spinal Cord Injury

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 65

Code: NCT02991248·Recruiting

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Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections

for Pulmonary Invasive Fungal Infections

32 locations incl. Little Rock

Sponsor: Arkansas Children's Hospital Research Institute

Sex: All·Age: 120 Days - 21

Code: NCT03827694·Recruiting

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Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

for Breast Cancer

451 locations incl. Fairbanks

Sponsor: Canadian Cancer Trials Group

Sex: Female·Age: 35+

Code: NCT03488693·Phase 3·Recruiting

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Phase 1 Study of INBRX-109 in Subjects With Locally Advanced or Metastatic Solid Tumors Including Sarcomas

for Ewing Sarcoma

23 locations incl. Scottsdale

Sponsor: Inhibrx Biosciences, Inc

Sex: All·Age: 12 - 85

Code: NCT03715933·Phase 1·Recruiting

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Pharmacokinetics and Safety of Commonly Used Drugs in Lactating Women and Breastfed Infants

for Lactating Women on Select DOI

20 locations incl. La Jolla

Sponsor: Duke University

Sex: All·Age: All ages

Code: NCT03511118·Recruiting

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The Course of Hip Flexion Weakness Following LLIF or ALIF

for Degenerative Disc Disease

1 location in Chicago

Sponsor: Rush University Medical Center

Sex: All·Age: Up to 65

Code: NCT04204135·Enrolling By Invitation

Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate Cancer

for Castration Levels of Testosterone

334 locations incl. Gilbert

Sponsor: SWOG Cancer Research Network

Sex: Male·Age: 18+

Code: NCT03678025·Phase 3·Recruiting

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Efficacy of Daromun Neoadjuvant Intratumoral Treatment in Clinical Stage IIIB/C/D Melanoma Patients

for Melanoma Stage IIIB

19 locations incl. Phoenix

Sponsor: Philogen S.p.A.

Sex: All·Age: 18+

Code: NCT03567889·Phase 3·Recruiting

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Extension Study for the Port Delivery System With Ranibizumab (Portal)

for Neovascular Age-Related Macular Degeneration

Drug: Ranibizumab

81 locations incl. Phoenix

Sponsor: Hoffmann-La Roche

Sex: All·Age: 50+

Code: NCT03683251·Phase 3·Recruiting

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S1703 Serum Tumor Marker Directed Disease Monitoring in Patients With Hormone Receptor Positive Her2 Negative Metastatic Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

709 locations incl. Anchorage

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT03723928·Recruiting

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Nivolumab With Ruxolitinib in Relapsed or Refractory Classical Hodgkin Lymphoma

for Hodgkin Lymphoma

Drug: Ruxolitinib

6 locations incl. Chicago

Sponsor: Veronika Bachanova

Sex: All·Age: 18+

Code: NCT03681561·Phase 1, Phase 2·Recruiting

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Selumetinib and Azacitidine in High Risk Chronic Blood Cancers

for Chronic Myeloid Leukemia

Drug: Selumetinib

1 location in Chicago

Sponsor: University of Chicago

Sex: All·Age: 18+

Code: NCT03326310·Phase 1·Recruiting

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Long-term Safety and Efficacy Extension Study for Participants With Advanced Tumors Who Are Currently on Treatment or in Follow-up in a Pembrolizumab (MK-3475) Study (MK-3475-587/KEYNOTE-587)

for Solid Tumors

65 locations incl. Tucson

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT03486873·Phase 3·Recruiting

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Advanced Materials Science in XLIF Study

for Degenerative Disc Disease

15 locations incl. Hartford

Sponsor: NuVasive

Sex: All·Age: 18 - 80

Code: NCT03649490·Enrolling By Invitation

Study of Sacituzumab Govitecan in Participants With Urothelial Cancer That Cannot Be Removed or Has Spread

for Metastatic Urothelial Cancer

37 locations incl. Tucson

Sponsor: Gilead Sciences

Sex: All·Age: 18+

Code: NCT03547973·Phase 2·Recruiting

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Continuous Positive Airway Pressure (CPAP) for Sleep Apnea in Pregnancy

for Obstructive Sleep Apnea of Adult

14 locations incl. Birmingham

Sponsor: The George Washington University Biostatistics Center

Sex: Female·Age: 18+

Code: NCT03487185·Recruiting

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Angelman Syndrome Natural History Study

for Angelman Syndrome

8 locations incl. Los Angeles

Sponsor: Boston Children's Hospital

Sex: All·Age: All ages

Code: NCT04507997·Recruiting

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ABL001 + Dasatinib + Prednisone + Blinatumomab in BCR-ABL+ B-ALL or CML

for B-cell Acute Lymphoblastic Leukemia

4 locations incl. Chicago

Sponsor: Marlise Luskin, MD

Sex: All·Age: 18+

Code: NCT03595917·Phase 1·Recruiting

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Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

for Neoplasms

100 locations incl. Birmingham

Sponsor: Celgene

Sex: All·Age: All ages

Code: NCT03435796·Phase 2, Phase 3·Recruiting

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A Study of the Safety and Tolerability of ASP7317 in Senior Adults Who Are Losing Their Clear, Sharp Central Vision Due to Geographic Atrophy Secondary to Dry Age-related Macular Degeneration

for Age-Related Macular Degeneration

19 locations incl. Phoenix

Sponsor: Astellas Institute for Regenerative Medicine

Sex: All·Age: 50+

Code: NCT03178149·Phase 1·Recruiting

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Efficacy and Safety of Oral Rifaximin in Patients With Active Microscopic Colitis

for Microscopic Colitis

1 location in Evanston

Sponsor: Eugene F Yen, MD

Sex: All·Age: 18+

Code: NCT04043897·Phase 2·Recruiting

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Intra-articular Platelet-Rich Plasma Compared With Viscosupplementation in the Treatment of Knee Osteoarthritis

for Knee Osteoarthritis

1 location in Skokie

Sponsor: Endeavor Health

Sex: All·Age: 18 - 75

Code: NCT03491761·Phase 2·Recruiting

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Ovarian Tissue Cryopreservation in Pre-Pubertal (OTC-Pre Pubertal)

for Cancers

1 location in Chicago

Sponsor: Erin Rowell

Sex: Female·Age: Up to 11

Code: NCT05299710·Recruiting

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Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)

for Ganglioneuroblastoma

152 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: 365 Days - 30

Code: NCT03126916·Phase 3·Recruiting

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Effect of Methadone and Hydromorphone on the QT Interval After Anesthesia and Surgery

for EKG-QT Prolongation

1 location in Evanston

Sponsor: Endeavor Health

Sex: All·Age: 18 - 80·Accepts healthy volunteers

Code: NCT03893734·Phase 4·Recruiting

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Longitudinal Early-onset Alzheimer's Disease Study Protocol

for Early Onset Alzheimer Disease

18 locations incl. Sun City

Sponsor: Indiana University

Sex: All·Age: 40 - 64·Accepts healthy volunteers

Code: NCT03507257·Recruiting

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International Registry of Congenital Portosystemic Shunt (IRCPSS)

for Congenital Portosystemic Shunt

2 locations incl. New Haven

Sponsor: Prof. Valérie Mc Lin

Sex: All·Age: 1 Day+

Code: NCT06041906·Enrolling By Invitation

Testing Osimertinib as a Treatment for Lung Cancers With an EGFR Exon 20 Change

for Advanced Lung Non-Small Cell Carcinoma

Drug: Osimertinib

345 locations incl. Anchorage

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03191149·Phase 2·Recruiting

Apply to this trial