Paid Clinical Trials in Illinois

Illinois has 2,972 paid clinical trials enrolling now across cities including Chicago, Peoria and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Illinois include Northwestern Medicine, University of Chicago Medicine and Rush, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 24, 2026.

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2,975 clinical trials

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CardioFocus HeartLight Post-Approval Study

for Atrial Fibrillation

4 locations incl. Tucson

Sponsor: CardioFocus

Sex: All·Age: 18+

Code: NCT03168659·Recruiting

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Initial Feasibility Study to Treat Borderline Resectable Pancreatic Cancer With a Planar LDR Source

for Pancreatic Cancer

6 locations incl. Tampa

Sponsor: CivaTech Oncology

Sex: All·Age: 18+

Code: NCT02843945·Phase 1, Phase 2·Recruiting

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Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

for Childhood Extracranial Germ Cell Tumor

566 locations incl. Birmingham

Sponsor: Children's Oncology Group

Sex: All·Age: All ages

Code: NCT03067181·Phase 3·Recruiting

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International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study)

for Squamous Cell Carcinoma of the Penis, Usual Type

11 locations incl. Los Angeles

Sponsor: Institute of Cancer Research, United Kingdom

Sex: Male·Age: 18+

Code: NCT02305654·Phase 3·Recruiting

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MammaPrint, BluePrint, and Full-genome Data Linked With Clinical Data to Evaluate New Gene EXpression Profiles

for Breast Cancer

130 locations incl. Birmingham

Sponsor: Agendia

Sex: All·Age: 18+

Code: NCT03053193·Recruiting

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Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

for Lung Neoplasm

17 locations incl. Long Beach

Sponsor: VA Office of Research and Development

Sex: All·Age: 18+

Code: NCT02984761·Recruiting

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Physica System Total Knee Replacement Registry Study

for Osteoarthritis, Knee

5 locations incl. Rancho Mirage

Sponsor: Limacorporate S.p.a

Sex: All·Age: 22+

Code: NCT03048201·Recruiting

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Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease

for Sickle Cell Disease

1 location in Chicago

Sponsor: University of Illinois at Chicago

Sex: All·Age: 16 - 60

Code: NCT03121001·Phase 2·Recruiting

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MILD® Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study

for Lumbar Spinal Stenosis

2307 locations incl. Athens

Sponsor: Stryker Instruments

Sex: All·Age: 18+

Code: NCT03072927·Recruiting

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A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

for Locally Advanced Solid Tumors

Drug: Repotrectinib

49 locations incl. Duarte

Sponsor: Turning Point Therapeutics, Inc.

Sex: All·Age: 12+

Code: NCT03093116·Phase 1, Phase 2·Recruiting

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PARTNER 3 Trial - Aortic Valve-in-Valve

for Aortic Stenosis

50 locations incl. Phoenix

Sponsor: Edwards Lifesciences

Sex: All·Age: All ages

Code: NCT03003299·Recruiting

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Retinoblastoma Patient Clinical Database and Tissue Repository

for Retinoblastoma

8 locations incl. Phoenix

Sponsor: Children's Hospital Los Angeles

Sex: All·Age: 0 - 18

Code: NCT04959097·Recruiting

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Transformative Research in Diabetic Nephropathy

for Diabetic Nephropathies

17 locations incl. Little Rock

Sponsor: University of Pennsylvania

Sex: All·Age: 18 - 100

Code: NCT02986984·Recruiting

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A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical Study

for Prostate Cancer

50 locations incl. Anchorage

Sponsor: Astellas Pharma Global Development, Inc.

Sex: Male·Age: 18+

Code: NCT02960022·Phase 2·Recruiting

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The Myelin Disorders Biorepository Project

for Leukodystrophy

23 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: All ages

Code: NCT03047369·Recruiting

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Study of Ruxolitinib in Relapsed or Refractory T or NK Cell Lymphoma

for Lymphoma

Drug: Ruxolitinib

10 locations incl. Miami

Sponsor: Memorial Sloan Kettering Cancer Center

Sex: All·Age: 18+

Code: NCT02974647·Phase 2·Recruiting

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Study of Biomarker-Based Treatment of Acute Myeloid Leukemia

for Previously Untreated Relapsed Refractory Acute Myeloid Leukemia

19 locations incl. Phoenix

Sponsor: Beat AML, LLC

Sex: All·Age: 18+

Code: NCT03013998·Phase 1, Phase 2·Recruiting

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Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

for Head and Neck Squamous Cell Carcinoma

676 locations incl. Birmingham

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT02734537·Phase 2·Recruiting

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Effect of Intermittent Hypoxia in Healthy Individuals

for Healthy

1 location in Chicago

Sponsor: Shirley Ryan AbilityLab

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT04691518·Enrolling By Invitation

Late Onset Alzheimer's Disease

for Alzheimer Disease

12 locations incl. Washington D.C.

Sponsor: Columbia University

Sex: All·Age: 55+·Accepts healthy volunteers

Code: NCT05010603·Recruiting

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SVS VQI TransCarotid Revascularization Surveillance Project

for Carotid Artery Disease

1 location in Chicago

Sponsor: Society for Vascular Surgery Patient Safety Organization

Sex: All·Age: 18+

Code: NCT02850588·Recruiting

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Pediatric Ovarian Tissue Banking - Operative Specimens From Females 0-18 Years of Age

for Benign Cysts Ovarian

1 location in Chicago

Sponsor: Ann & Robert H Lurie Children's Hospital of Chicago

Sex: Female·Age: Up to 18·Accepts healthy volunteers

Code: NCT04118712·Recruiting

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MEASuRE: Metreleptin Effectiveness And Safety Registry

for Generalised Lipodystrophy

16 locations incl. Birmingham

Sponsor: Amryt Pharma

Sex: All·Age: All ages

Code: NCT02325674·Recruiting

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Women Informed to Screen Depending on Measures of Risk (Wisdom Study)

for Breast Cancer Screening

11 locations incl. Birmingham

Sponsor: University of California, San Francisco

Sex: Female·Age: 30 - 74·Accepts healthy volunteers

Code: NCT02620852·Recruiting

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Optune Delivered Electric Field Therapy and Bevacizumab in Treating Patients With Recurrent or Progressive Grade 2 or 3 Meningioma

for Anaplastic (Malignant) Meningioma

Drug: Bevacizumab

8 locations incl. Santa Monica

Sponsor: Northwestern University

Sex: All·Age: 18+

Code: NCT02847559·Phase 2·Recruiting

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Anti-mullerian Hormone Levels in Healthy Females

for Healthy

1 location in Chicago

Sponsor: Erin Rowell

Sex: Female·Age: Up to 18·Accepts healthy volunteers

Code: NCT04537390·Recruiting

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Impact of Sulphonylureas on Neurodevelopmental Outcomes in KCNJ11-related Intermediate Developmental Delay, Epilepsy and Neonatal Diabetes (iDEND) Syndrome

for Neurodevelopmental Disorders

1 location in Chicago

Sponsor: Royal Devon and Exeter NHS Foundation Trust

Sex: All·Age: 2 - 50

Code: NCT05751525·Recruiting

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Quality Improvement and Practice Based Research in Neurology Using the EMR

for Brain Tumors

1 location in Evanston

Sponsor: Endeavor Health

Sex: All·Age: 18 - 100

Code: NCT02670161·Phase 4·Enrolling By Invitation

Prospective Research Rare Kidney Stones (ProRKS)

for Hyperoxaluria

8 locations incl. Birmingham

Sponsor: Mayo Clinic

Sex: All·Age: All ages

Code: NCT02780297·Recruiting

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National Collaborative to Improve Care of Children With Complex Congenital Heart Disease

for Hypoplastic Left Heart Syndrome (HLHS)

61 locations incl. Birmingham

Sponsor: Children's Hospital Medical Center, Cincinnati

Sex: All·Age: Up to 15 Months

Code: NCT02852031·Recruiting

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Quality of Pediatric Resuscitation in a Multicenter Collaborative

for Cardiac Arrest

40 locations incl. Los Angeles

Sponsor: Children's Hospital of Philadelphia

Sex: All·Age: 0 - 18

Code: NCT02708134·Recruiting

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Proton Radiation for Unresectable, Borderline Resectable, or Medically Inoperable Carcinoma of the Pancreas

for Pancreatic Cancer

4 locations incl. Jacksonville

Sponsor: Proton Collaborative Group

Sex: All·Age: 18+

Code: NCT02598349·Phase 2·Recruiting

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Early PKD Observational Cohort Study

for Polycystic Kidney Disease

3 locations incl. Chicago

Sponsor: University of Kansas Medical Center

Sex: All·Age: 4 - 35·Accepts healthy volunteers

Code: NCT02936791·Recruiting

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Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

for Community-acquired Pneumonia, Influenza, COVID-19

11 locations incl. Jacksonville

Sponsor: UMC Utrecht

Sex: All·Age: 18+

Code: NCT02735707·Phase 3·Recruiting

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TAPUR: Testing the Use of Food and Drug Administration (FDA) Approved Drugs That Target a Specific Abnormality in a Tumor Gene in People With Advanced Stage Cancer

for Lymphoma, Non-Hodgkin

174 locations incl. Birmingham

Sponsor: American Society of Clinical Oncology

Sex: All·Age: 12+

Code: NCT02693535·Phase 2·Recruiting

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A Clinical Registry of Orthobiologics Procedures

for Orthopedic Disorder

30 locations incl. Phoenix

Sponsor: Regenexx, LLC

Sex: All·Age: All ages

Code: NCT03011398·Enrolling By Invitation

Improving the Quality of Care for Adults With Inflammatory Bowel Disease

for Crohn's Disease

29 locations incl. Los Angeles

Sponsor: Dartmouth-Hitchcock Medical Center

Sex: All·Age: 18 - 99

Code: NCT02791854·Enrolling By Invitation

Neurocognition in Congenital Central Hypoventilation Syndrome (CCHS)

for Congenital Central Hypoventilation Syndrome

4 locations incl. Los Angeles

Sponsor: Debra Weese-Mayer

Sex: All·Age: 3 - 85

Code: NCT03568669·Recruiting

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TSC Biosample Repository and Natural History Database

for Tuberous Sclerosis

24 locations incl. Birmingham

Sponsor: National Tuberous Sclerosis Association

Sex: All·Age: All ages

Code: NCT05676099·Recruiting

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Development and Validation of Patient Reported Outcome (PRO) Measures for Individuals With Neurofibromatosis 1 (NF1) and Plexiform Neurofibromas (pNFs)

for Neurofibromatosis 1

6 locations incl. Washington D.C.

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT02544022·Recruiting

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