Paid Clinical Trials in Massachusetts

Massachusetts has 3,602 paid clinical trials enrolling now across cities including Boston, Worcester and Springfield. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in Massachusetts include Mass General Hospital, Dana-Farber and Brigham and Women's, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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3,602 clinical trials

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A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

for Breast Neoplasms

46 locations incl. Chandler

Sponsor: Merck Sharp & Dohme LLC

Sex: All·Age: 18+

Code: NCT06312176·Phase 3·Recruiting

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Aptis PRUJ Prosthesis for the Treatment of Patients With Proximal Radial Ulna Joint Disorders.

for Arthritis

7 locations incl. Carmel

Sponsor: Aptis Medical

Sex: All·Age: 18 - 85·Accepts healthy volunteers

Code: NCT05796908·Recruiting

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Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function

for Heart Failure and Impaired Kidney Function

Drug: Dapagliflozin

166 locations incl. Alexander City

Sponsor: AstraZeneca

Sex: All·Age: 18 - 130

Code: NCT06307652·Phase 3·Recruiting

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Forecasting Seizures Using Intelligent Wearable Technology for Health Tracking

for Epilepsy

1 location in Boston

Sponsor: Empatica, Inc.

Sex: All·Age: 6+

Code: NCT06275685·Recruiting

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Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations

for Non-Small Cell Lung Cancer

Drug: Rilvegostomig

63 locations incl. Anchorage

Sponsor: AstraZeneca

Sex: All·Age: 18+

Code: NCT06357533·Phase 3·Recruiting

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Mindfulness-Based fMRI Neurofeedback for Depression

for Depression in Adolescence

2 locations incl. Boston

Sponsor: Columbia University

Sex: All·Age: 13 - 18

Code: NCT05617495·Recruiting

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Language During Inhalational Induction

for Emergence Delirium

1 location in Boston

Sponsor: Boston Children's Hospital

Sex: All·Age: 5 - 10

Code: NCT06324955·Recruiting

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Prevention of GvHD in Participants With Hematological Malignancies Undergoing Hematopoietic Stem Cell Transplant (HSCT)

for Hematologic Malignancy

5 locations incl. Duarte

Sponsor: Tr1X, Inc.

Sex: All·Age: 18+

Code: NCT06462365·Phase 1·Recruiting

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AAA-SHAPE Pivotal Trial: Abdominal Aortic Aneurysm Sac Healing and Prevention of Expansion

for Aortic Aneurysm, Abdominal

39 locations incl. Birmingham

Sponsor: Shape Memory Medical, Inc.

Sex: All·Age: 18+

Code: NCT06029660·Recruiting

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Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne

for Acne

79 locations incl. Scottsdale

Sponsor: Sanofi Pasteur, a Sanofi Company

Sex: All·Age: 18 - 45

Code: NCT06316297·Phase 1, Phase 2·Recruiting

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Patient-Reported Outcomes and Quality of Life in Adult and Pediatric Patients With Nodular Lymphocyte-Predominant Hodgkin Lymphoma (NLPHL)

for Nodular Lymphocyte-Predominant Hodgkin Lymphoma

7 locations incl. Palo Alto

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: 8+

Code: NCT06098430·Recruiting

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Asthma Link Effectiveness Trial

for Childhood Asthma

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 5 - 14

Code: NCT06388460·Recruiting

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Researching Efficient Approaches to Delirium Identification-Sustaining Effective Translation

for Delirium

2 locations incl. Boston

Sponsor: Penn State University

Sex: All·Age: 70+

Code: NCT05915377·Recruiting

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A Hybrid Effectiveness Implementation Trial Evaluating Behavioral Treatments for Insomnia for Socioeconomically Disadvantaged Adults in Primary Care

for Insomnia

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT05759065·Recruiting

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Metabolic Effects of Adjunctive Lumateperone Treatment in Clozapine-Treated Patients With Schizophrenia

for Schizophrenia

1 location in Worcester

Sponsor: University of Massachusetts, Worcester

Sex: All·Age: 18 - 65

Code: NCT06174116·Phase 4·Recruiting

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Biomarkers Research in Anxiety for Validation and Efficacy

for Autism

1 location in Brookline

Sponsor: Boston Children's Hospital

Sex: All·Age: 3 - 6

Code: NCT06221176·Recruiting

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First In Human Study of CX-2051 in Advanced Solid Tumors

for Solid Tumor, Adult

7 locations incl. Denver

Sponsor: CytomX Therapeutics

Sex: All·Age: 18+

Code: NCT06265688·Phase 1·Recruiting

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A Long-term Follow-up Study to Evaluate SKG0106 in the Treatment of Patients With nAMD

for Neovascular (Wet) Age-related Macular Degeneration

3 locations incl. Boston

Sponsor: Skyline Therapeutics

Sex: All·Age: 50+

Code: NCT06346600·Recruiting

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Impulsivity Domains and Subjective Response

for Alcohol Use Disorder

2 locations incl. Boston

Sponsor: Jessica Weafer

Sex: All·Age: 21 - 25·Accepts healthy volunteers

Code: NCT05929677·EARLY_Phase 1·Recruiting

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Breathe Easier With Tadalafil Therapy for Dyspnea in COPD-PH

for Chronic Obstructive Pulmonary Disease

5 locations incl. Aurora

Sponsor: VA Office of Research and Development

Sex: All·Age: 35 - 89

Code: NCT05937854·Phase 2·Recruiting

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Evaluation of Safety, Immunogenicity and Efficacy of a Triple Immune Regimen in Adults Initiated on ART During Acute HIV-1

for HIV-1-infection

10 locations incl. San Diego

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

Sex: All·Age: 18+

Code: NCT06071767·Phase 1, Phase 2·Recruiting

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Pilot of 18F-DCFPyL-PSMA PET in mCRPC Patients Receiving 117Lu-Vipivotide Tetraxetan

for Prostate Cancer

2 locations incl. Boston

Sponsor: Brigham and Women's Hospital

Sex: Male·Age: 18+

Code: NCT06099093·Phase 4·Recruiting

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A Study to Assess Change in Disease Activity and Adverse Events (AE)s in Adult Participants With Immunoglobulin Light Chain (AL) Amyloidosis Receiving Etentamig (ABBV-383) as an Intravenous (IV) Infusion

for Immunoglobulin Light Chain (AL) Amyloidosis

Drug: Etentamig

12 locations incl. Miami

Sponsor: AbbVie

Sex: All·Age: 18+

Code: NCT06158854·Phase 1, Phase 2·Recruiting

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Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis

for Cystic Fibrosis

1 location in Boston

Sponsor: Massachusetts General Hospital

Sex: All·Age: 13 - 20·Accepts healthy volunteers

Code: NCT06216704·Recruiting

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Copper Cu 64 PSMA I&T PET Imaging in Men With Newly Diagnosed Prostate Cancer

for Prostate Cancer

44 locations incl. Homewood

Sponsor: Curium US LLC

Sex: Male·Age: 18+

Code: NCT06235151·Phase 3·Recruiting

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A Phase 1/2 Study to Investigate CRB-701 in Solid Tumors

for Solid Tumor, Adult

15 locations incl. Birmingham

Sponsor: Corbus Pharmaceuticals Inc.

Sex: All·Age: 18+

Code: NCT06265727·Phase 1, Phase 2·Recruiting

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Digital Health Navigation for Latino Patients With Type II Diabetes

for Type 2 Diabetes

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 18+

Code: NCT06283992·Recruiting

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Study of Ravulizumab in Immunoglobulin A Nephropathy (IgAN)

for Immunoglobulin A Nephropathy

46 locations incl. Alabaster

Sponsor: Alexion Pharmaceuticals, Inc.

Sex: All·Age: 18+

Code: NCT06291376·Phase 3·Recruiting

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An Observational Study in Subjects to Follow the Progression of Stargardt Disease Type 1 (STGD1) Caused by Bi-Allelic Autosomal Recessive Mutations in the ABCA4 Gene

for Stargardt

14 locations incl. San Diego

Sponsor: Splice Bio

Sex: All·Age: 12 - 65

Code: NCT06435000·Recruiting

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A Study to Evaluate the Safety, Tolerability, Efficacy, and Drug Levels of CC-97540 in Participants With Relapsing Forms of Multiple Sclerosis, Progressive Forms of Multiple Sclerosis or Refractory Myasthenia Gravis (MG) (Breakfree-2)

for Multiple Sclerosis

17 locations incl. Birmingham

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18 - 60

Code: NCT06220201·Phase 1·Recruiting

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Resistance and Aerobic Exercise for Prevention in Women With Dense Breasts (REP-D)

for Breast Cancer

2 locations incl. Boston

Sponsor: Dana-Farber Cancer Institute

Sex: Female·Age: 18 - 59·Accepts healthy volunteers

Code: NCT06322888·Recruiting

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Reversible Effect of Falling Ventilatory Drive in Drive-dependent OSA

for OSA

1 location in Boston

Sponsor: Brigham and Women's Hospital

Sex: All·Age: 21 - 80

Code: NCT06091098·Recruiting

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Promoting Shared Decision Making for Severe Aortic Stenosis

for Aortic Stenosis

8 locations incl. San Francisco

Sponsor: Massachusetts General Hospital

Sex: All·Age: 65 - 85

Code: NCT06171737·Enrolling By Invitation

A Study of Participants With Cerebral Adrenoleukodystrophy (CALD) Treated With Elivaldogene Autotemcel

for Cerebral Adrenoleukodystrophy (CALD)

3 locations incl. Boston

Sponsor: Genetix Biotherapeutics Inc.

Sex: Male·Age: All ages

Code: NCT06224413·Recruiting

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NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS)

for Adipocytic Neoplasm

Drug: Selinexor

7 locations incl. Atlanta

Sponsor: St. Jude Children's Research Hospital

Sex: All·Age: Up to 30

Code: NCT06239272·Phase 1, Phase 2·Recruiting

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A Study Evaluating the Presence and Concentration of BRIUMVI™ (Ublituximab) in Breast Milk

for Relapsing Multiple Sclerosis

5 locations incl. San Francisco

Sponsor: TG Therapeutics, Inc.

Sex: Female·Age: 18+

Code: NCT06143514·Recruiting

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Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults With PKP2 Mutation-associated ARVC

for Arrhythmogenic Right Ventricular Cardiomyopathy

7 locations incl. San Francisco

Sponsor: Tenaya Therapeutics

Sex: All·Age: 18 - 65

Code: NCT06228924·Phase 1·Recruiting

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Preventing Depression of Chinese American Adolescents by RRE

for Subclinical Depressive Symptoms

1 location in Boston

Sponsor: Northeastern University

Sex: All·Age: 14 - 18·Accepts healthy volunteers

Code: NCT05921201·Recruiting

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The REBALANCE Study - a Prospective, Multicenter, Randomized, Pivotal Study of the May Health System

for Polycystic Ovary Syndrome

24 locations incl. Encino

Sponsor: May Health

Sex: Female·Age: 18 - 40

Code: NCT06206746·Recruiting

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A Phase 1/1b Study of IAM1363 in HER2 Cancers

for HER2 Mutation-Related Tumors

29 locations incl. La Jolla

Sponsor: Iambic Therapeutics, Inc

Sex: All·Age: 18+

Code: NCT06253871·Phase 1·Recruiting

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