Paid Clinical Trials in North Carolina

North Carolina has 2,944 paid clinical trials enrolling now across cities including Durham, Chapel Hill and Winston-Salem. Search by condition, age, or phase to find compensated research studies accepting participants near you.

Research sites in North Carolina include Duke University Medical Center, UNC Health and Wake Forest Baptist, running studies across oncology, cardiology, neurology, and more. Both patients and healthy volunteers may qualify. Most studies offer compensation for time and travel.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 19, 2026.

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2,944 clinical trials

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A Study to Evaluate Tovorafenib in Pediatric and Young Adult Participants With Relapsed or Progressive Low-Grade Glioma and Advance Solid Tumors

for Low-grade Glioma

14 locations incl. San Francisco

Sponsor: Day One Biopharmaceuticals, Inc.

Sex: All·Age: 6 Months - 25

Code: NCT04775485·Phase 2·Recruiting

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R21: An Easy-to-use, iNtelligent, Affordable LinEr (ENABLE) System for Socket Fit Assessment

for Lower Limb Amputation Below Knee (Injury)

1 location in Raleigh

Sponsor: North Carolina State University

Sex: All·Age: 18 - 99

Code: NCT05425810·Recruiting

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A Long-term Treatment Extension Study of Niraparib in Participants Who Completed a Prior GlaxoSmithKline/TESARO-sponsored Niraparib Study

for Ovarian Neoplasms

Drug: Niraparib

13 locations incl. Tucson

Sponsor: GlaxoSmithKline

Sex: All·Age: 18+

Code: NCT04641247·Phase 2·Recruiting

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Open-Label Study of mRNA-3927 in Participants With Propionic Acidemia

for Propionic Acidemia

15 locations incl. Los Angeles

Sponsor: ModernaTX, Inc.

Sex: All·Age: All ages

Code: NCT04159103·Phase 1, Phase 2·Recruiting

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Testing the Addition of an Individualized Vaccine to Durvalumab and Tremelimumab and Chemotherapy in Patients With Metastatic Triple Negative Breast Cancer

for Anatomic Stage IV Breast Cancer AJCC v8

Drug: Tremelimumab

30 locations incl. Orange

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT03606967·Phase 2·Recruiting

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A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

for High Grade Glioma

10 locations incl. Aurora

Sponsor: Nationwide Children's Hospital

Sex: All·Age: Up to 21

Code: NCT04655404·EARLY_Phase 1·Recruiting

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Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature

for Peripheral Vascular Diseases

52 locations incl. Jonesboro

Sponsor: Boston Scientific Corporation

Sex: All·Age: 18+

Code: NCT04674969·Recruiting

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DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

for Medulloblastoma

23 locations incl. Little Rock

Sponsor: Giselle Sholler

Sex: All·Age: Up to 21

Code: NCT04696029·Phase 2·Recruiting

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Post-market Surveillance Study of the BD® WavelinQ™ EndoAVF System

for Kidney Disease, End-Stage

16 locations incl. La Jolla

Sponsor: C. R. Bard

Sex: All·Age: 18+

Code: NCT04634916·Recruiting

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Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years

for Motor Function

16 locations incl. Scottsdale

Sponsor: Guerbet

Sex: All·Age: 18 - 64

Code: NCT04373564·Phase 4·Recruiting

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A Study to Test the Safety and Tolerability of Brivaracetam in Children and Adolescents With Seizures

for Epilepsy

2 locations incl. Hawthorne

Sponsor: UCB Biopharma SRL

Sex: All·Age: 1 Month+

Code: NCT04715646·Phase 3·Recruiting

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Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

for Advanced Solid Tumor Cancer

Drug: ABBV-CLS-484

15 locations incl. Tucson

Sponsor: Calico Life Sciences LLC

Sex: All·Age: 18+

Code: NCT04777994·Phase 1·Recruiting

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Comparing the Outcome of Immunotherapy-Based Drug Combination Therapy With or Without Surgery to Remove the Kidney in Metastatic Kidney Cancer, the PROBE Trial

for Metastatic Clear Cell Renal Cell Carcinoma

387 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 18+

Code: NCT04510597·Phase 3·Recruiting

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Fatty Acid Synthase Inhibition in Castration Refractory Prostate Cancer

for Prostate Cancer

2 locations incl. Salisbury

Sponsor: Wake Forest University Health Sciences

Sex: Male·Age: 18+

Code: NCT04337580·Phase 2·Recruiting

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Fenofibrate for Prevention of DR Worsening

for Diabetic Retinopathy

66 locations incl. Glendale

Sponsor: Jaeb Center for Health Research

Sex: All·Age: 18 - 80

Code: NCT04661358·Phase 3·Recruiting

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Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on RecoverY

for Ischemic Stroke

31 locations incl. Phoenix

Sponsor: Massachusetts General Hospital

Sex: All·Age: 18+

Code: NCT04916210·Recruiting

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A Study of Axatilimab at 3 Different Doses in Participants With Chronic Graft Versus Host Disease (cGVHD)

for Chronic Graft-versus-host-disease

47 locations incl. Birmingham

Sponsor: Syndax Pharmaceuticals

Sex: All·Age: 2+

Code: NCT04710576·Phase 2·Recruiting

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Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study

for Chronic Lymphocytic Leukemia

620 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04269902·Phase 3·Recruiting

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Opioid Treatment and Peer Recovery Support

for Opioid-use Disorder

3 locations incl. Durham

Sponsor: Brown University

Sex: All·Age: 18+

Code: NCT04978168·Recruiting

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Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial

for Plasma Cell Myeloma

642 locations incl. Anchorage

Sponsor: ECOG-ACRIN Cancer Research Group

Sex: All·Age: 18+

Code: NCT04566328·Phase 3·Recruiting

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Single-Sided Deafness and Asymmetric Hearing Loss

for Hearing Loss, Unilateral

5 locations incl. Chicago

Sponsor: Med-El Corporation

Sex: All·Age: 5+

Code: NCT04506853·Recruiting

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Randomized Phase IIB Trial of Oral Azacytidine Plus Romidepsin Versus Investigator's Choice in PTCL

for PTCL

6 locations incl. Long Beach

Sponsor: University of Virginia

Sex: All·Age: 18+

Code: NCT04747236·Phase 2·Recruiting

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PANTHER Study of Terumo Aortic Knitted and Woven Grafts, and Cardiovascular Patches

for Aneurysm

10 locations incl. Aurora

Sponsor: Vascutek Ltd.

Sex: All·Age: 18+

Code: NCT04545502·Recruiting

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Sepsis Clinical Decision Support [CDS] Master Enrollment Study Protocol

for Severe Sepsis

10 locations incl. Irvine

Sponsor: Beckman Coulter, Inc.

Sex: All·Age: 18 - 89

Code: NCT05304728·Enrolling By Invitation

Study to Test OBI-3424 in Patients With T-Cell Acute Lymphoblastic Leukemia (T-ALL) or T-Cell Lymphoblastic Lymphoma (T-LBL)

for Recurrent T Acute Lymphoblastic Leukemia

163 locations incl. Birmingham

Sponsor: SWOG Cancer Research Network

Sex: All·Age: 12+

Code: NCT04315324·Phase 1, Phase 2·Recruiting

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Femoral Peri-arterial Local Anesthetic Injection Via Peri-arterial Perineural Catheter Reverses Tourniquet Associated Ischemic Hypertension

for Tourniquet Hypertension

1 location in Durham

Sponsor: Duke University

Sex: All·Age: 18 - 75·Accepts healthy volunteers

Code: NCT04454203·Phase 4·Recruiting

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ARDS in Children and ECMO Initiation Strategies Impact on Neurodevelopment (ASCEND)

for Acute Respiratory Distress Syndrome

76 locations incl. Birmingham

Sponsor: University of Michigan

Sex: All·Age: 14 Days - 20

Code: NCT05388708·Recruiting

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Beat Childhood Cancer Specimen Banking and Data Registry

for Pediatric Cancer

18 locations incl. Little Rock

Sponsor: Giselle Sholler

Sex: All·Age: All ages·Accepts healthy volunteers

Code: NCT04715178·Recruiting

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Annuloplasty Rings and Band Post-Market Clinical Follow-Up Study

for Mitral Regurgitation

2 locations incl. Durham

Sponsor: Abbott Medical Devices

Sex: All·Age: 18+

Code: NCT04761120·Recruiting

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Aimovig Pregnancy Exposure Registry

for Migraine

1 location in Durham

Sponsor: Amgen

Sex: Female·Age: 18 - 99·Accepts healthy volunteers

Code: NCT06150781·Recruiting

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Prebiotic Galacto-oligosaccharide and Acute GVHD

for Acute GVHD

2 locations incl. Kansas City

Sponsor: University of Kansas Medical Center

Sex: All·Age: 18 - 80

Code: NCT04373057·Phase 1, Phase 2·Recruiting

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Surgery With or Without Neoadjuvant Chemotherapy in High Risk RetroPeritoneal Sarcoma

for Retroperitoneal Sarcoma

109 locations incl. Birmingham

Sponsor: European Organisation for Research and Treatment of Cancer - EORTC

Sex: All·Age: 18+

Code: NCT04031677·Phase 3·Recruiting

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A Long-term Follow-up Study in Participants Who Received CTX001

for Beta-Thalassemia

9 locations incl. Palo Alto

Sponsor: Vertex Pharmaceuticals Incorporated

Sex: All·Age: 2+

Code: NCT04208529·Phase 3·Enrolling By Invitation

Quantitation and Spatial Registration of Airways Dysfunction With Dynamic 19F MRI in Cystic Fibrosis

for Cystic Fibrosis

1 location in Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 18 - 99

Code: NCT06057714·Recruiting

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The Biomarkers in the Hyperbaric Oxygen Brain Injury Treatment Trial (BioHOBIT)

for Traumatic Brain Injury

10 locations incl. San Diego

Sponsor: University of Michigan

Sex: All·Age: 16 - 65

Code: NCT04855396·Recruiting

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Randomized Study in Children and Adolescents With Migraine: Acute Treatment

for Pediatric Migraine

169 locations incl. Birmingham

Sponsor: Pfizer

Sex: All·Age: 6 - 17

Code: NCT04649242·Phase 3·Recruiting

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Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

for Locally Advanced Pancreatic Adenocarcinoma

Drug: Peposertib

44 locations incl. Duarte

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04172532·Phase 1, Phase 2·Recruiting

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Vibration and Post-traumatic Osteoarthritis Risk Following ACL Injury

for Osteoarthritis, Knee

2 locations incl. Chapel Hill

Sponsor: University of North Carolina, Chapel Hill

Sex: All·Age: 16 - 35

Code: NCT04875052·Recruiting

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Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial

for Extensive Stage Lung Small Cell Carcinoma

Drug: Atezolizumab

416 locations incl. Birmingham

Sponsor: National Cancer Institute (NCI)

Sex: All·Age: 18+

Code: NCT04402788·Phase 2, Phase 3·Recruiting

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Lung B.A.S.E.S. 4 Life Mobile Low-dose Computed Tomography (LDCT) Screening: Ages 40-54

for Lung Neoplasms

1 location in Charlotte

Sponsor: Wake Forest University Health Sciences

Sex: All·Age: 40 - 54·Accepts healthy volunteers

Code: NCT04577599·Recruiting

Apply to this trial