Clinical Trials at Columbia University Irving Medical Center

As of June 2026, 185 paid clinical trials are recruiting at Columbia University Irving Medical Center in New York, New York. Compensation typically covers time, travel, and study visits — most studies also offer study-related medical care at no cost to participants.

Recruiting trial data synced daily from ClinicalTrials.gov. Last sync: June 3, 2026.

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185 clinical trials at Columbia University Irving Medical Center

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Avutometinib and Defactinib in Diffuse Gastric Cancer

for Gastric Cancer

Drug: Avutometinib

1 location in New York

Sponsor: Ryan H. Moy, MD, PhD

Sex: All·Age: 18+

Code: NCT06487221·Phase 2·Recruiting

Apply to this trial

Diazoxide Suppression Test P&F Study

for Insulin Resistance

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65

Code: NCT06606327·Phase 1·Recruiting

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Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)

for Liver Neoplasms

29 locations incl. Fullerton

Sponsor: HistoSonics, Inc.

Sex: All·Age: 22+

Code: NCT06486454·Recruiting

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Gluten Technology and Education for Celiac Health

for Celiac Disease

4 locations incl. Chicago

Sponsor: Columbia University

Sex: All·Age: 18 - 75

Code: NCT06059716·Recruiting

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CD5-deleted Chimeric Antigen Receptor Cells (Senza5 CART5) for T Cell Non-Hodgkin Lymphoma (NHL)

for T Cell Non-Hodgkin Lymphoma

2 locations incl. New York

Sponsor: Vittoria Biotherapeutics

Sex: All·Age: 18+

Code: NCT06420089·Phase 1·Recruiting

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Graded Insulin Suppression Test P&F

for Insulin Resistance

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 65·Accepts healthy volunteers

Code: NCT06592261·Phase 1·Recruiting

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Low and High Flow Suctioning in Intubated Infants

for Respiratory Failure

1 location in New York

Sponsor: Columbia University

Sex: All·Age: Up to 28 Days

Code: NCT06443970·Recruiting

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DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes

for Gestational Diabetes Mellitus

21 locations incl. Tuscaloosa

Sponsor: Ohio State University

Sex: Female·Age: 18+

Code: NCT06445946·Phase 4·Recruiting

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Prediction of Anxiety and Memory State

for Anxiety

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 55

Code: NCT06551090·Recruiting

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RESET-SSc: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201, a CD19-CAR T Cell Therapy, in Subjects With Systemic Sclerosis

for Systemic Sclerosis

10 locations incl. New Haven

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 75

Code: NCT06328777·Phase 1, Phase 2·Recruiting

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A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

for Metastatic Solid Tumor

Drug: LY4052031

17 locations incl. Duarte

Sponsor: Eli Lilly and Company

Sex: All·Age: 18+

Code: NCT06465069·Phase 1·Recruiting

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Mechanistic Effect of Walnut Consumption on Sleep Quality

for Poor Sleep Quality

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 45 - 65·Accepts healthy volunteers

Code: NCT06430086·Recruiting

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Cognitive Control Targets for the Treatment of Obsessive Compulsive Disorder in Young Children

for Obsessive-Compulsive Disorder in Children

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 8 - 12

Code: NCT06102941·Recruiting

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KiteLock 4% EDTA Lock Solution for the Prevention of Occlusions in Children With Intestinal Failure

for Pediatric Intestinal Failure

8 locations incl. Boston

Sponsor: SterileCare Inc.

Sex: All·Age: 4 Weeks - 18

Code: NCT05879835·Recruiting

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Study of BMS-986497 (ORM-6151) as a Monotherapy, in Double and Triple Combination With Azacitidine and Venetoclax in Participants With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome

for Acute Myeloid Leukemia

Drug: Venetoclax

9 locations incl. New Haven

Sponsor: Bristol-Myers Squibb

Sex: All·Age: 18+

Code: NCT06419634·Phase 1·Recruiting

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Combination Therapy in Patients With Localized Pancreatic Ductal Adenocarcinoma

for Pancreatic Ductal Adenocarcinoma

5 locations incl. Lake Success

Sponsor: Gulam Manji

Sex: All·Age: 18+

Code: NCT06048484·Phase 2·Recruiting

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Screening for AL Amyloidosis in Smoldering Multiple Myeloma

for Smoldering Multiple Myeloma

13 locations incl. Birmingham

Sponsor: Tufts Medical Center

Sex: All·Age: 40+

Code: NCT06365060·Recruiting

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Establishing Walking-related Digital Biomarkers in Rare Childhood Onset Progressive Neuromuscular Disorders

for Spinal Muscular Atrophy Type 3

3 locations incl. Palo Alto

Sponsor: Columbia University

Sex: All·Age: 5+·Accepts healthy volunteers

Code: NCT06839469·Recruiting

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Human Models of Selective Insulin Resistance: Alpelisib, Part I

for Insulin Resistance

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 70·Accepts healthy volunteers

Code: NCT06354088·Phase 1·Recruiting

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Mindfulness-Based fMRI Neurofeedback for Depression

for Depression in Adolescence

2 locations incl. Boston

Sponsor: Columbia University

Sex: All·Age: 13 - 18

Code: NCT05617495·Recruiting

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A Trial to Evaluate the Safety and Efficacy of Benfotiamine in Patients With Early Alzheimer's Disease (BenfoTeam)

for Alzheimer Disease

47 locations incl. Phoenix

Sponsor: Alzheimer's Disease Cooperative Study (ADCS)

Sex: All·Age: 50 - 89

Code: NCT06223360·Phase 2·Recruiting

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Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

for Alpha1-Antitrypsin Deficiency

20 locations incl. Phoenix

Sponsor: Takeda

Sex: All·Age: 18 - 75

Code: NCT06165341·Phase 3·Recruiting

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Physiological Effects of Continuous Negative External Pressure for Acute Hypoxemic Respiratory Failure

for Acute Hypoxemic Respiratory Failure

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 18+

Code: NCT05675345·Recruiting

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RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

for Systemic Lupus Erythematosus

21 locations incl. Orange

Sponsor: Cabaletta Bio

Sex: All·Age: 18 - 65

Code: NCT06121297·Phase 1, Phase 2·Recruiting

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Needs Navigation for Caregivers of AYAs

for Cancer in Adolescence

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 15 - 26·Accepts healthy volunteers

Code: NCT06296641·Enrolling By Invitation

A Study to Learn How Nusinersen (Spinraza) Affects Participants With Spinal Muscular Atrophy (SMA) Who Took it Before or During Pregnancy And About The Health of Their Babies

for Muscular Atrophy, Spinal

4 locations incl. Palo Alto

Sponsor: Biogen

Sex: Female·Age: 18 - 54

Code: NCT05789758·Recruiting

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A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma

for Choroidal Melanoma

36 locations incl. Birmingham

Sponsor: Aura Biosciences

Sex: All·Age: 18+

Code: NCT06007690·Phase 3·Recruiting

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Food FARMacia: Reducing Childhood Obesity in Households With Food Insecurity

for Nutrition, Healthy

2 locations incl. Stanford

Sponsor: Stanford University

Sex: All·Age: 6 Months+

Code: NCT06051591·Recruiting

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Safety, PK, and Preliminary Efficacy of MBRC-101 in Advanced Refractory Solid Tumors

for Cancer

17 locations incl. San Francisco

Sponsor: MBrace Therapeutics

Sex: All·Age: 18+

Code: NCT06014658·Phase 1, Phase 2·Recruiting

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Global Multicenter Registry on Transcatheter TRIcuspid Valve RePLACEment

for Tricuspid Regurgitation

5 locations incl. Phoenix

Sponsor: Montefiore Medical Center

Sex: All·Age: 18+

Code: NCT06033274·Recruiting

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A Study to Investigate Why Overweight People Regain Weight After Losing Weight in a Behavioral Weight Loss Program

for Obesity

3 locations incl. New York

Sponsor: University of Pittsburgh

Sex: All·Age: 25 - 59

Code: NCT05748158·Recruiting

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Impact of Yo-Yo Sleep on Cardiometabolic Health

for Cardiometabolic Syndrome

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 18 - 49·Accepts healthy volunteers

Code: NCT05880758·Recruiting

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Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

for Lumbar Spinal Stenosis

6 locations incl. Beverly Hills

Sponsor: Columbia University

Sex: All·Age: 50+·Accepts healthy volunteers

Code: NCT06034405·Recruiting

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A Study of CC-97540, CD-19-Targeted Nex-T CAR T Cells, in Participants With Severe, Refractory Autoimmune Diseases (Breakfree-1)

for Systemic Lupus Erythematosus

31 locations incl. Aurora

Sponsor: Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

Sex: All·Age: 18+

Code: NCT05869955·Phase 1·Recruiting

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A Study of ASKG915 in Patients With Selected Advanced Solid Tumors.

for Advanced Solid Tumors

2 locations incl. New York

Sponsor: AskGene Pharma, Inc.

Sex: All·Age: 18+

Code: NCT05867420·Phase 1, Phase 2·Recruiting

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European Prospective Investigation Into Childhood Cancer

for Acute Lymphoblastic Leukemia

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 3 - 21

Code: NCT05375617·Recruiting

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Study of N-acetylcysteine in the Treatment of Patients With the m.3243A>G Mutation and Low Brain Glutathione Levels

for Mitochondrial Disease

1 location in New York

Sponsor: Michio Hirano, MD

Sex: All·Age: 18 - 80

Code: NCT05241262·Phase 1·Recruiting

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A Study of DB-OTO, an Adeno-Associated Virus (AAV) Based Gene Therapy, in Children/Infants With Hearing Loss Due to Otoferlin Mutations

for Congenital Hearing Loss Secondary to Biallelic Mutations of the Otoferlin Gene (OTOF)

9 locations incl. Los Angeles

Sponsor: Regeneron Pharmaceuticals

Sex: All·Age: Up to 17

Code: NCT05788536·Phase 1, Phase 2·Recruiting

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Alzheimer's Disease Neuroimaging Initiative 4

for Mild Cognitive Impairment

59 locations incl. Birmingham

Sponsor: University of Southern California

Sex: All·Age: 55 - 90·Accepts healthy volunteers

Code: NCT05617014·Enrolling By Invitation

FUS Etoposide for DMG

for Diffuse Intrinsic Pontine Glioma

1 location in New York

Sponsor: Columbia University

Sex: All·Age: 4 - 21

Code: NCT05762419·Phase 1·Recruiting

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