Bevacizumab in Treating Patients With Angiosarcoma

Part of paid clinical trials in La Jolla, California.

Sponsor
Northwestern University
Study ID
NCT00288015
Phase
PHASE2
Status
Completed

Conditions

  • Sarcoma

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Bevacizumab — BIOLOGICAL
    Bevacizumab 15 mg/kg IV infusion given on day 1 every 21 days = (1 cycle).

Study Details

RATIONALE: Monoclonal antibodies, such as bevacizumab, can block tumor growth in different ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the growth of tumor cells by blocking blood flow to the tumor. PURPOSE: This phase II trial is studying how well bevacizumab works in treating patients with angiosarcoma.

Key Dates

First listed
Feb 7, 2006
Start date
Oct 31, 2005
Status verified
Jun 2018
Primary completion
Jun 6, 2013
Completion
Nov 10, 2016

Study Design

Enrollment
32 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Bevacizumab
    Bevacizumab treatment until disease progression or intolerance

Primary Outcome Measure

Median Progression-free Survival of Patients Treated With the Study Drug as Defined by RECIST Criteria. [ Time Frame: After cycles 2 and 4, then every 3 cycles thereafter while on treatment (1 cycle = 21 days); every 3-4 months after treatment up to 2 years. ]

Locations (5)

FacilityCityStateZIPSite coordinators
Rebecca and John Moores UCSD Cancer CenterLa JollaCalifornia92093-0658-
Robert H. Lurie Comprehensive Cancer Center at Northwestern UniversityChicagoIllinois60611-3013-
Mayo Clinic Cancer CenterRochesterMinnesota55905-
Fox Chase Cancer Center CCOP Research BasePhiladelphiaPennsylvania19140-
M. D. Anderson Cancer Center at University of TexasHoustonTexas77030-4009-

Find similar trials in La Jolla, CA

By research site
Rebecca and John Moores UCSD Cancer Center· La Jolla, CARobert H. Lurie Comprehensive Cancer Center at Northwestern University· Chicago, ILMayo Clinic Cancer Center· Rochester, MNFox Chase Cancer Center CCOP Research Base· Philadelphia, PAM. D. Anderson Cancer Center at University of Texas· Houston, TX

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