Vorinostat and Rituximab in Treating Patients With Indolent Non-Hodgkin Lymphoma

Part of paid clinical trials in Beverly Hills, California.

Sponsor
City of Hope Medical Center
Study ID
NCT00720876
Phase
PHASE2
Status
Completed

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • rituximab — BIOLOGICAL
    Rituximab will be administered at a dose of 375 mg/m2 on day 1 of every cycle, every 3 weeks.
  • vorinostat — DRUG
    200 mg twice daily, orally for 14 days followed by a seven day break on a 21 day cycle.

Study Details

RATIONALE: Vorinostat may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Giving vorinostat together with rituximab may kill more cancer cells. PURPOSE: This phase II trial is studying the side effects of giving vorinostat together with rituximab and to see how well it works in treating patients with indolent non-Hodgkin lymphoma.

Key Dates

Start date
Jul 23, 2008
Status verified
Jul 2018
Primary completion
Jun 8, 2017
Completion
Jun 8, 2017

Study Design

Enrollment
30 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: Vorinostat and Rituximab
    Vorinostat by mouth two times (2X) per day for two weeks followed by one week of rest. Rituximab intravenously once every three weeks .

Primary Outcome Measure

Overall Response Rate (Complete and Partial Response) [ Time Frame: After every 3 cycles, up to 1 year after the start of treatment ]

Locations (3)

FacilityCityStateZIPSite coordinators
Tower Cancer Research FoundationBeverly HillsCalifornia90211-
City of Hope Comprehensive Cancer CenterDuarteCalifornia91010-3000-
City of Hope Medical GroupPasadenaCalifornia91105-

Find similar trials in Beverly Hills, CA

By research site
Tower Cancer Research Foundation· Beverly Hills, CACity of Hope Comprehensive Cancer Center· Duarte, CACity of Hope Medical Group· Pasadena, CA

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