Intrapleural Bevacizumab and Cisplatin Therapy for Malignant Pleural Effusion Caused by Non-small Cell Lung Cancer
- Sponsor
- Chinese PLA General Hospital
- Study ID
- NCT01661790
- Phase
- PHASE3
- Status
- Completed
Conditions
- Malignant Pleural Effusion
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 85 Years
- Healthy Volunteers
- Not accepted
Interventions
- Bevacizumab — DRUGBevacizumab300mg\&Cispltin30mg by intrapleural administration of each 2 week
- Cisplatin — DRUGCisplatin 30mg,intrapleural administration,each 2 week
Study Details
To determine the efficacy and Safety of intrapleural Bevacizumab and cisplatin as a treatment for malignant pleural effusions (MPE) in patients with non-small cell lung cancer (NSCLC).
Key Dates
- First listed
- Aug 10, 2012
- Start date
- Aug 31, 2009
- Status verified
- Mar 2015
- Primary completion
- Jun 30, 2012
- Completion
- Oct 31, 2012
Study Design
- Enrollment
- 72 participants (actual)
- Allocation
- RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- TREATMENT
Arms
- Experimental: Bevacizumab & CisplatinBevacizumab 300mg plus Cisplatin 30mg by intrapleural given every two weeks
- Active Comparator: CisplatinCisplatin 30mg by intrapleural given every two weeks
Primary Outcome Measure
Number of Participants With "Complete Response" and "Partial Response" [ Time Frame: from randomization, This treatment was given every two weeks,responses were made by biweekly ]
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