Study of Pembrolizumab With Chemotherapy in Patients With Advanced Lymphoma (PembroHeme)

Part of paid clinical trials in Goodyear, Arizona.

Sponsor
Western Regional Medical Center
Study ID
NCT02408042
Phase
PHASE1/PHASE2
Status
Withdrawn

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Pembrolizumab — DRUG
  • Etoposide — DRUG
  • Ifosfamide — DRUG
  • Mesna — DRUG
  • Carboplatin — DRUG
  • Brentuximab vedotin — DRUG
  • Rituximab — DRUG

Study Details

To determine the recommended phase 2 dose of chemotherapy in combination with Pembrolizumab in subjects with advanced lymphoma and determine the complete response rate.

Key Dates

Start date
Apr 30, 2015
Status verified
Dec 2015
Primary completion
Nov 30, 2015
Completion
Nov 30, 2015

Study Design

Enrollment
0 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Active Comparator: RICE and Pembrolizumab
    non-Hodgkin's lymphoma patients requiring 2nd line or beyond therapy and eligible to receive RICE (rituximab, ifosfamide, carboplatin, and etoposide)
  • Active Comparator: ICE and Pembrolizumab
    classical Hodgkin's lymphoma requiring 2nd line or beyond therapy and eligible to receive ICE (ifosfamide, carboplatin, and etoposide)
  • Active Comparator: brentuximab vedotin and Pembrolizumab
    classical Hodgkin's lymphoma that have progressed after high-dose chemotherapy with autologous stem cell rescue or progressed on at least 2 lines of therapy and are eligible to receive brentuximab vedotin

Primary Outcome Measure

Determine the recommended phase 2 dose (RP2D) of chemotherapy in combination with pembrolizumab (pembro) in subjects with advanced lymphoma and complete remission by Revised Response Criteria for Malignant Lymphoma. [ Time Frame: up to 12 weeks ]

Locations (1)

FacilityCityStateZIPSite coordinators
Cancer Treatment Center of America @ Western Regional Medical CenterGoodyearArizona85338-

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By research site
Cancer Treatment Center of America @ Western Regional Medical Center· Goodyear, AZ

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