Study of ACTR707 in Combination With Rituximab in Subjects With Relapsed or Refractory B Cell Lymphoma

Part of paid clinical trials in Gilbert, Arizona.

Sponsor
Cogent Biosciences, Inc.
Study ID
NCT03189836
Phase
PHASE1
Status
Terminated

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Not accepted

Interventions

  • ACTR707 — BIOLOGICAL
    autologous T cell product
  • rituximab — BIOLOGICAL
    CD20-directed cytolytic antibody

Study Details

This is a phase 1, multi-center, single-arm, open-label study evaluating the safety and anti-lymphoma activity of an autologous T cell product (ACTR707) in combination with rituximab in subjects with refractory or relapsed CD20+ B cell lymphoma.

Key Dates

Start date
Oct 4, 2017
Status verified
Oct 2021
Primary completion
Sep 21, 2020
Completion
Sep 21, 2020

Study Design

Enrollment
26 participants (actual)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: ACTR707 in combination with rituximab

Primary Outcome Measure

Safety as assessed by dose limiting toxicities (DLTs) [ Time Frame: 28 days ]

Locations (11)

FacilityCityStateZIPSite coordinators
Banner MD Anderson Cancer CenterGilbertArizona85234-
Yale UniversityNew HavenConnecticut06520-
Emory University, Winship Cancer InstituteAtlantaGeorgia30322-
Loyola UniversityMaywoodIllinois60153-
Indiana Bone and Marrow TransplantationIndianapolisIndiana46327-
University of MarylandBaltimoreMaryland21201-
University of MinnesotaMinneapolisMinnesota55455-
Ohio State UniversityColumbusOhio43210-
Tennessee Oncology - NashvilleNashvilleTennessee37203-
The University of Texas MD Anderson Cancer CenterHoustonTexas77030-
Medical College of WisconsinMilwaukeeWisconsin53226-

Find similar trials in Gilbert, AZ

By research site
Banner MD Anderson Cancer Center· Gilbert, AZYale University· New Haven, CTEmory University, Winship Cancer Institute· Atlanta, GALoyola University· Maywood, ILIndiana Bone and Marrow Transplantation· Indianapolis, INUniversity of Maryland· Baltimore, MD

Related Studies