The Pharmacokinetics/Pharmacodynamics and Safety/Tolerability of Evogliptin in Hemodialysis Patients
- Sponsor
- Dong-A ST Co., Ltd.
- Study ID
- NCT04195919
- Phase
- PHASE1
- Status
- Completed
Conditions
- Hemodialysis Patients
Eligibility Criteria
- Sex
- ALL
- Age
- 20 Years - 80 Years
- Healthy Volunteers
- Accepted
Interventions
- Evogliptin 5mg — DRUGParticipants receive Single oral administration of Evogliptin 5mg on day1
- Evogliptin 5mg — DRUGPeriod 1(1d,After hemodialysis) → Wash-out period → Period 2(15d,Before hemodialysis) Hemodialysis patients receive Single oral administration of Evogliptin 5mg on day1 and day15 With a 14-day washout period
Study Details
A clinical study to investigate the pharmacokinetics/ pharmacodynamics and safety/tolerability of Evogliptin in hemodialysis patients
Key Dates
- First listed
- Dec 12, 2019
- Start date
- Jul 10, 2020
- Status verified
- Nov 2021
- Primary completion
- May 24, 2021
- Completion
- May 24, 2021
Study Design
- Enrollment
- 17 participants (actual)
- Allocation
- NON_RANDOMIZED
- Intervention model
- PARALLEL
- Primary purpose
- HEALTH_SERVICES_RESEARCH
Arms
- Experimental: Group1Hemodialysis patients(MDRD-eGFR ≤ 15 mL/min/1.73m2)
- Experimental: Group2Healthy control(MDRD-eGFR ≥ 90 mL/min/1.73m2)
Primary Outcome Measure
AUClast [ Time Frame: 1day(15day) pre-dose (0), 1, 2, 3, 4, 5, 6, 7, 8, 12, 24, 36, 48 hour post-dose ]