Substituting Sitting With Standing and Walking in Free-living Conditions Improves Daily Glucose Profile in South Asians

Sponsor
University of Bedfordshire
Study ID
NCT04645875
Status
Completed

Conditions

  • Cardiovascular Diseases
  • Cardiovascular Risk Factor
  • Diabetes
  • Sedentary Behavior
  • Sedentary Lifestyle
  • Type 2 Diabetes

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • SIT regimen — OTHER
    See SIT regimen arm description
  • SITless regimen — OTHER
    See SITless regimen arm description

Study Details

The purpose of this study is to investigate the effects of substituting sitting under free-living conditions in South Asian adults with overweight and obesity on continuous glucose profiles.

Key Dates

Start date
Nov 19, 2020
Status verified
Mar 2026
Primary completion
Jul 31, 2021
Completion
Jul 31, 2021

Study Design

Enrollment
18 participants (actual)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: SIT regimen, then SITless regimen
    Firstly, participants performed the SIT regimen (4 days) where they were instructed to restrict walking to ≤1 h/day and standing to ≤1 h/day during their waking day. Participants were allowed to perform their daily activities, including cooking and other household activities, within the 2-h of permitted walking and standing. After a washout period of 3 days, they then performed the SITless regimen (4 days). SIT regimen: See SIT regimen arm description SITless regimen: See SITless regimen arm description
  • Experimental: SITless regimen, then SIT regimen
    Firstly, participants performed the SITLess regimen (4 days) where they were instructed to substitute a minimum of 5-h/day sitting with ≥3-h of standing and ≥2-h of self-perceived LPA in addition to interrupting their sitting for 2-5-min every 30-min. A list of activities (including walking at a slow pace, walking on the spot, jumping up and down, and standing) was provided as examples of activities that particpants could perform during this regimen. After a washout period of 3 days, they then performed the SIT regimen (4 days). SITless regimen: See SITless regimen arm description SIT regimen: See SIT regimen arm description

Primary Outcome Measure

Glycaemia [ Time Frame: Mean net incremental area under the curve for waking hours (16 h) interstitial glucose concentration per day for 4 valid days during each intervention ]

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