A Study of LY3437943 in Participants With Impaired and Normal Liver Function

Part of paid clinical trials in Chandler, Arizona.

Sponsor
Eli Lilly and Company
Study ID
NCT05916560
Phase
PHASE1
Status
Completed

Conditions

  • Healthy
  • Hepatic Insufficiency

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • LY3437943 — DRUG
    Administered SC.

Study Details

The main purpose of this study is to measure how much of LY3437943 gets into the bloodstream and how long it takes the body to eliminate it in participants with mild, moderate and severe impaired liver function compared to healthy participants with normal liver function. The safety and tolerability of LY3437943 will also be evaluated. The study may last up to 9 weeks for each participant including the screening period.

Key Dates

Start date
Jul 13, 2023
Status verified
Apr 2025
Primary completion
Mar 2, 2025
Completion
Mar 2, 2025

Study Design

Enrollment
43 participants (actual)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: LY3437943 (Normal Hepatic Function)
    LY3437943 administered subcutaneously (SC).
  • Experimental: LY3437943 (Severe Hepatic Impairment)
    LY3437943 administered SC.
  • Experimental: LY3437943 (Moderate Hepatic Impairment)
    LY3437943 administered SC.
  • Experimental: LY3437943 (Mild Hepatic Impairment)
    LY3437943 administered SC.

Primary Outcome Measure

Pharmacokinetics (PK): Area under the concentration versus time curve from time zero to infinity (AUC0-∞) of LY3437943 [ Time Frame: Predose up to 30 days postdose ]

Locations (5)

FacilityCityStateZIPSite coordinators
Arizona Clinical Trials - ChandlerChandlerArizona85225-
Accel Research Sites- Clinical Research UnitDeLandFlorida32720-
Advanced Pharma Clinical ResearchMiamiFlorida33147-4040-
American Research Corporation at Texas Liver InstituteSan AntonioTexas78215-
Pinnacle Clinical ResearchSan AntonioTexas78229-

Find similar trials in Chandler, AZ

By research site
Arizona Clinical Trials - Chandler· Chandler, AZAccel Research Sites- Clinical Research Unit· DeLand, FLAdvanced Pharma Clinical Research· Miami, FLAmerican Research Corporation at Texas Liver Institute· San Antonio, TXPinnacle Clinical Research· San Antonio, TX

Related Studies