Combined Anti-IL6R and Anticoagulation Therapy in Advanced NPC Patients

Sponsor
Affiliated Hospital of Nantong University
Study ID
NCT06442709
Status
Unknown

Conditions

  • Nasopharyngeal Carcinoma

Eligibility Criteria

Sex
ALL
Age
20 Years - 70 Years
Healthy Volunteers
Not accepted

Interventions

  • Tocilizumab Asprin — DRUG
    Tocilizumab alone, Asprin alone, Tocilizumab combined with Asprin. Tocilizumab, an IL6R inhibitor, injected once a month at a dose of 4mg/kg in advanced NPC patients. Asprin，an anticoagulant, taken orally once daily at a dose of 100mg in advanced NPC patients.
  • Placebo — OTHER
    Placebo replaces tocilizumab and asprin in advanced NPC patients.

Study Details

The investigators have demonstrated the crucial role of the liver-lung axis in the distant metastasis of NPC. Furthermore, the investigators have identified a potential therapeutic approach to improve outcomes in NPC patients by identifying those most suitable for anticoagulant therapy. Further, the combination of anticoagulant therapy and anti-IL6R therapy has shown promising results in enhancing the prognosis of NPC patients. These findings highlight the significance of targeting the liver-lung axis and utilizing personalized treatment strategies for NPC.

Key Dates

Start date
Aug 1, 2021
Status verified
Mar 2024
Primary completion
Jul 1, 2024
Completion
Jul 1, 2024

Study Design

Enrollment
100 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Combined Anti-IL6R and Anticoagulation Therapy in Advanced NPC Patients
    Tocilizumab, an IL6R inhibitor, injected once a month at a dose of 4mg/kg in advanced NPC patients. Asprin，an anticoagulant, taken orally once daily at a dose of 100mg in advanced NPC patients.
  • Placebo Comparator: Receive placebo in Advanced NPC Patients
    Placebo replaces tocilizumab and asprin in advanced NPC patients.

Primary Outcome Measure

Tumor progression and metastasis [ Time Frame: Five to Ten years ]

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