Neural Circuit Mechanism of Inflammatory Bowel Disease Combined With Depression

Sponsor
LanZhou University
Study ID
NCT06471894
Status
Not Yet Recruiting

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Conditions

  • Inflammatory Bowel Diseases

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Magnetic resonance imaging scanning — RADIATION
    Perform brain diffusion imaging, magnetic resonance spectroscopy, and functional magnetic resonance imaging scans on all individuals
  • FMT Protocol — DRUG
    Treatment of disease groups (UC and CD) using prepared fecal microbiota transplantation solution

Study Details

The goal of this observational study is to understand the effects of gut microbiota dysbiosis treatment in patients with inflammatory bowel disease (IBD) combined with depression. The main question it aims to answer is: Does fecal microbiota transplantation (FMT) improve depression symptoms in IBD patients by altering GABA levels in the medial prefrontal cortex? Participants already undergoing fecal microbiota transplantation (FMT) as part of their regular medical care for IBD and comorbid depression will undergo regular assessments of GABA levels, gut microbiota, and depression symptoms for the duration of the study.

Key Dates

First listed
Jun 24, 2024
Start date
Jul 1, 2024
Status verified
Jun 2024
Primary completion
Jul 1, 2024
Completion
Dec 1, 2027

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: CD
    Crohn's disease
  • Arm: UC
    ulcerative colitis
  • Arm: HC
    healthy controls

Primary Outcome Measure

Magnetic resonance spectroscopy [ Time Frame: 1 week before and 1 week after FMT ]

Central Contacts

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