Neurofilament Light Chain Correlation With Severity of Symptoms and Cognitive Decline in Mood Disorders

Sponsor
Assiut University
Study ID
NCT06877442
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Mood Disorders

Eligibility Criteria

Sex
ALL
Age
15 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • serum level of neurofilament light chain — DIAGNOSTIC_TEST
    labarotory investigation to evaluate serum level of neurofilament light chain

Study Details

* Explore correlation of neurofilament light chain serum level and severity of symptoms and cognitive impairment in mood disorders * Explore How novel brain markers as neurofilament light chain can be useful in detection and prognosis of mood disorders

Key Dates

First listed
Mar 14, 2025
Start date
May 1, 2025
Status verified
Mar 2025
Primary completion
Nov 1, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
90 participants (estimated)

Arms

  • Arm: group A Patients with major depression
    meet the Diagnostic And Statistical Manual Of Mental Disorders Fifth Edition (DSM-5) criteria for major depressive disorder they will undergo the following 1. Hamilton depression rating scale 2. montreal cognitive assessment c, serum level of neurofilament light chain
  • Arm: group B Bipolar Disorder
    meet the Diagnostic And Statistical Manual Of Mental Disorders Fifth Edition (DSM-5) criteria for Bipolar Disorder they will undergo the following 1. young mania rating scale 2. montreal cognitive assessment 3. serum level of neurofilament light chain
  • Arm: group C healthy control
    not known to have any medical or mental illness they will undergo the following 1. montreal cognitive assessment 2. serum level of neurofilament light chain

Primary Outcome Measure

correlation of neurofilament light chain with severity of symptoms in mood disorders [ Time Frame: baseline ]

Central Contacts

Related Studies