ANI-Guided Anesthetic Desflurane Consumption

Sponsor
Wonkwang University Hospital
Study ID
NCT06982209
Status
Recruiting
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Conditions

  • General Anesthesia
  • Laparoscopic Cholecystectomy
  • Postoperative Pain

Eligibility Criteria

Sex
ALL
Age
19 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Analgesia/Nociception Index (ANI) — DEVICE
    ANI was monitored using the ANI monitor (MetroDoloris, France) in both groups, but only guided adjustments in the ANI group

Study Details

General anesthesia requires precise titration of inhaled anesthetics like desflurane and opioids like remifentanil to balance sedation, analgesia, and hemodynamic stability. The Analgesia/Nociception Index (ANI), derived from heart rate variability (HRV), quantifies parasympathetic tone to assess nociception-antinociception balance on a 0-100 scale, with lower values indicating nociceptive stress. ANI analyzes high-frequency HRV components, reflecting parasympathetic inhibition during painful stimuli, making it a reliable indicator of intraoperative nociception. Studies validate the utility of ANI in detecting nociceptive events during laparoscopic surgery. ANI-guided opioid titration reduces opioid consumption and stabilizes hemodynamics, enhancing perioperative outcomes.

Key Dates

First listed
May 21, 2025
Start date
Jul 2, 2026
Status verified
Jul 2026
Primary completion
Jul 30, 2026
Completion
Aug 30, 2026

Study Design

Enrollment
125 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: ANI-guided group
    Desflurane started at 1 MAC (\~6 Vol%), titrated in 0.1 MAC increments to maintain ANI 50-70 and BIS 40-60. ANI \<50 prompted an increase; ANI \>70 prompted a decrease
  • Active Comparator: Control group
    Desflurane was titrated based on vital signs (heart rate, blood pressure) and BIS 40-60, per institutional protocol.

Primary Outcome Measure

Mean End-Tidal Desflurane Concentration [ Time Frame: From induction of anesthesia to end of surgery (approximately 60 minutes) ]

Central Contacts

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