Comparative Analysis of Delirium in Older Adults Treated With Ceftazidime, Cefepime, or Ceftriaxone

Sponsor
Alexandria University
Study ID
NCT07026253
Status
Recruiting
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Conditions

  • Delirium

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The goal of this observational study is to learn if the use of ceftazidime, cefepime, and ceftriaxone impacts the incidence of delirium in elderly patients (aged 65 and older) with infections. The main questions it aims to answer are: Does the administration of these antibiotics increase the incidence of delirium in elderly patients? How do renal and hepatic dose adjustments affect the likelihood of delirium? Researchers will observe elderly patients receiving either ceftazidime, cefepime, or ceftriaxone for infection management to see if these antibiotics contribute to the onset of delirium, and then assessing the severity of the delirium. Participants will: Be assessed for delirium using the CAM (Confusion Assessment Method) at 2, 4, and 6 days after starting treatment. Have their QSOFA (Quick Sequential Organ Failure Assessment) and NEWS (National Early Warning Score) tracked to evaluate their overall health status. Undergo dose adjustments based on renal and hepatic function as part of their treatment. Use the DRS.R89 score to assess delirium if it occurred.

Key Dates

First listed
Jun 18, 2025
Start date
Oct 1, 2024
Status verified
Aug 2024
Primary completion
Sep 30, 2025
Completion
Dec 31, 2025

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Ceftazidime Group
    A cohort of at least 40 older-adult patients (≥65 years) receiving ceftazidime for the treatment of various infections.
  • Arm: Cefepime Group
    A group of a minimum of 40 elderly patients treated with cefepime for confirmed or suspected infections.
  • Arm: Ceftriaxone Group
    This cohort will include at least 40 older adult inpatients receiving ceftriaxone as part of their anti-infective regimen

Primary Outcome Measure

Incidence of Delirium Diagnosed by Confusion Assessment Method (CAM) [ Time Frame: Within 6 days after initiation of antibiotic treatment ]

Central Contacts

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