Biomarkers in the Endometrial Fluid, Tissue, and Follicular Fluid of Moderate/Severe Endometriosis Patients

Sponsor
Region Stockholm
Study ID
NCT07182643
Status
Not Yet Recruiting

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Conditions

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Endometrial fluid — DIAGNOSTIC_TEST
    Endometrial fluid collection in the day of OPU
  • Endometrial biopsy — DIAGNOSTIC_TEST
    Endometrial biopsy on the OPU day, Pipelle
  • Follicular fluid — DIAGNOSTIC_TEST
    Follicular fluid sampling on the OPU day

Study Details

This study aims to explore biomarkers in the endometrial fluid and tissue of women with moderate to severe endometriosis, with a specific focus on those involved in pre-receptive endometrium and embryo implantation. This research has the potential to uncover diagnostic indicators of impaired pre-receptive endometrium, examine pathophysiological pathways, and identify future targets for therapeutic intervention. Ultimately, the findings may contribute to more personalized fertility treatments, offering new hope for women struggling with endometriosis-related infertility.

Key Dates

First listed
Sep 19, 2025
Start date
Oct 1, 2025
Status verified
Sep 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
90 participants (estimated)

Arms

  • Arm: Endometriosis
    Moderate/severe endometriosis
  • Arm: Controls
    Healthy women undergoing oocyte pick up

Primary Outcome Measure

Relative expression levels (e.g., fold change, normalized intensity, or concentration in pg/mL/ng/mL depending on biomarker assay) [ Time Frame: 2 years ]

Central Contacts

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