MRI Role in Knee Hemophilic Arthopathy

Sponsor
Assiut University
Study ID
NCT07233122
Status
Not Yet Recruiting

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Conditions

  • Arthropathy Hemophilic
  • Arthropathy of Knee
  • Hemophilia
  • MRI

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The aim of this study is to assess role of MRI in detecting synovial, cartilaginous , osseous abnormalities ، bleeding inside knee joint and to use a system for assessing HA as support for therapeutic regimes and for monitoring response to therapy .

Key Dates

Start date
Dec 1, 2025
Status verified
Nov 2025
Primary completion
Dec 1, 2027
Completion
Dec 1, 2027

Study Design

Enrollment
95 participants (estimated)

Arms

  • Arm: MRI in Knee Hemophilic Arthopathy
    Participants diagnosed with hemophilia and clinical suspicion of knee arthropathy will undergo magnetic resonance imaging (MRI) of the affected knee. MRI will be performed using standardized sequences to evaluate joint changes, including synovial hypertrophy, hemosiderin deposition, cartilage thinning, and bone damage. Findings will be scored using the International Prophylaxis Study Group (IPSG) MRI scoring system.
  • Arm: Xray in Knee Hemophilic Arthropathy
    Participants diagnosed with hemophilia and clinical suspicion of knee arthropathy will undergo conventional radiography (X-ray) of the affected knee. Standard anteroposterior and lateral views will be obtained to evaluate joint changes, including joint space narrowing, osteoporosis, subchondral cysts, erosions, and bone deformities. Findings will be scored using the Pettersson X-ray scoring system.

Primary Outcome Measure

International Prophylaxis Study Group (IPSG) MRI Score for Hemophilic Arthropathy [ Time Frame: After completion of MRI scanning session (within the same study visit). Overall Study Duration: 2 years (for recruitment, imaging, and data analysis). ]

Central Contacts

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