Velocity-Based Resistance Training in Kidney Transplant Recipients

Sponsor
Fundación Universitaria del Area Andina
Study ID
NCT07370727
Status
Recruiting
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Conditions

  • Cardiovascular Risk Factors
  • Kidney Transplant Recipients
  • Metabolic Syndrome

Eligibility Criteria

Sex
ALL
Age
18 Years - 50 Years
Healthy Volunteers
Not accepted

Interventions

  • Velocity-Based Resistance Training - Submaximal Velocity Protocol — OTHER
    A 12-week supervised resistance training program performed 3 sessions per week. Exercises will include bench press, squat, and shoulder press in Smith machine. Participants will execute each repetition at \~50% of maximal concentric velocity, with sets completed according to predetermined repetitions (20-30 depending on load, 20-60% 1RM).
  • Velocity-Based Resistance Training - Maximal Velocity Protocol — OTHER
    A 12-week supervised resistance training program performed 3 sessions per week. Exercises will include bench press, squat, and shoulder press in Smith machine. Participants will execute each repetition at maximal concentric velocity, with sets terminated at 20% velocity loss. Training loads will increase progressively (20-60% 1RM).

Study Details

This randomized controlled trial aims to evaluate the effects of velocity-based resistance training on renal function and metabolic health in kidney transplant recipients. Participants will be randomized into two groups performing resistance training at different execution velocities (maximal intended vs. submaximal controlled). The intervention will last 12 weeks and include multi-joint exercises (squat, bench press, military press). Primary outcomes include renal function (serum creatinine, eGFR, blood urea nitrogen, uric acid) and metabolic markers (HDL, triglycerides, glucose, waist circumference, blood pressure). Secondary outcomes include muscle strength, force-velocity profile, anthropometry, physical activity, fitness perception, and adherence to immunosuppressive medication.

Key Dates

First listed
Jan 27, 2026
Start date
Oct 29, 2025
Status verified
Jan 2026
Primary completion
Jun 1, 2026
Completion
Dec 31, 2027

Study Design

Enrollment
12 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Experimental - Maximal Velocity Group
    Participants will perform velocity-based resistance training at maximal intended concentric velocity. Training load will progress from 20% to 60% of 1RM. Each set will be terminated once a 20% loss of movement velocity is reached.
  • Active Comparator: Submaximal Velocity Group
    Participants will perform supervised velocity-based resistance training for 12 weeks, 3 sessions per week. Each repetition will be executed at approximately 50% of maximal concentric velocity. Training load will progress from 20% to 60% of 1RM, with sets completed according to a predetermined number of repetitions (20-30 depending on load).

Primary Outcome Measure

Serum creatinine (mg/dL) - change from baseline [ Time Frame: Baseline and week 13 (after completion of 12-week intervention) ]

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