Cardiovascular Phenotypes in Sepsis

Sponsor
Karolinska Institutet
Study ID
NCT07442032
Status
Not Yet Recruiting

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Conditions

  • Cardiovascular Dysfunction
  • Microcirculatory Dysfunction
  • Peripheral Vascular Response
  • Sepsis
  • Septic Shock
  • Troponin Elevation

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

This prospective observational study will investigate cardiovascular phenotypes in adults with sepsis and hemodynamic instability. Approximately 400 patients requiring vasopressor support will be enrolled across multiple hospital sites. Within 72 hours of admission, participants will undergo peripheral vascular assessments, echocardiography, and blood sampling for cardiac, endothelial, and inflammatory biomarkers. Patients will be classified according to the presence or absence of peripheral vascular dysfunction and cardiac dysfunction. The primary aim is to examine the association between these cardiovascular phenotypes and one-year mortality. Secondary aims include evaluating biomarker profiles, characterizing myocardial injury, and assessing cardiac function at a 3-month follow-up. The study seeks to improve understanding of sepsis-related cardiovascular dysfunction and support development of more individualized management strategies.

Key Dates

First listed
Mar 2, 2026
Start date
Apr 6, 2026
Status verified
Feb 2026
Primary completion
May 1, 2028
Completion
Dec 31, 2029

Study Design

Enrollment
400 participants (estimated)

Arms

  • Arm: Adults with suspected sepsis and hemodynamic instability requiring vasopressor support.
    Participants are enrolled prospectively across multiple hospital sites and undergo standardized assessments of peripheral vascular function, echocardiography, and biomarker sampling. No interventions are assigned as part of the study.

Primary Outcome Measure

Association between cardiovascular phenotypes and one-year mortality in sepsis [ Time Frame: Up to 1 year after admission to the Intermediate Care Unit (IMCU), Intensive Care Unit (ICU) or Cardiac Care Unit (CCU). ]

Central Contacts

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