Effects of Nicotine Dependence on Multidimensional Health Outcomes

Sponsor
Izmir Democracy University
Study ID
NCT07474623
Status
Not Yet Recruiting

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Conditions

  • Nicotine Dependence, Cigarettes
  • Tobacco Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Accepted

Interventions

  • Comprehensive Clinical Assessment — OTHER
    Participants will undergo a comprehensive clinical assessment including evaluation of nicotine dependence level (Fagerström Test for Nicotine Dependence), respiratory muscle strength (MIP, MEP), functional capacity (6-Minute Walk Test), cognitive function (MoCA), pain (VAS and SF-MPQ), quality of life (SF-36), physical activity level (IPAQ-SF), sleep quality (PSQI), addiction behavior model (SOCRATES), and health beliefs (Health Belief Model Scale). No therapeutic intervention will be administered.

Study Details

Nicotine, a major toxic component of cigarette smoke, together with carbon monoxide (CO), constitutes a significant environmental exposure with systemic effects. Beyond its addictive potential, chronic nicotine exposure may induce inflammation, oxidative stress, tissue hypoxia, and autonomic imbalance, potentially impairing respiratory muscle strength, functional capacity, and overall physical performance. Additionally, nicotine dependence has been associated with sleep disturbances, cognitive dysfunction, altered pain perception, and reduced quality of life. Although previous studies have examined individual effects of smoking on specific health outcomes, research addressing these multidimensional impacts within a comprehensive framework remains limited. Therefore, this study aims to investigate the relationship between nicotine dependence level and respiratory muscle strength, functional capacity, cognitive functions, pain, quality of life, physical activity level, and sleep quality, in order to provide a more holistic understanding of the clinical consequences of nicotine dependence.

Key Dates

First listed
Mar 16, 2026
Start date
Apr 15, 2026
Status verified
Mar 2026
Primary completion
Apr 15, 2027
Completion
Jul 15, 2027

Study Design

Enrollment
212 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER

Arms

  • Other: Adult Smokers
    Adult individuals who use cigarettes will be enrolled in this observational study. Participants will be evaluated for nicotine dependence level using the Fagerström Test for Nicotine Dependence and will undergo assessments of respiratory muscle strength (MIP, MEP), functional capacity (6-Minute Walk Test), cognitive function (MoCA), pain (VAS/SF-MPQ), quality of life (SF-36), physical activity level (IPAQ-SF), sleep quality (PSQI), addiction behavior model (SOCRATES), and health beliefs (Health Belief Model Scale). No intervention will be applied.

Primary Outcome Measure

Assessment of Nicotine Dependence [ Time Frame: At baseline ]

Central Contacts

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