Cardiovascular Acoustics for Early Disease Detection

Sponsor
Cambridge University Hospitals NHS Foundation Trust
Study ID
NCT07496775
Status
Not Yet Recruiting

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Conditions

  • Coronary Artery Disease
  • Valvular Heart Disease

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

There are many types of heart disease. Two of the most common causes are narrowings within the blood vessels that supply the heart (known as coronary artery disease), or valves within the heart becoming narrowed (stenosed) or leaky (regurgitation), known as heart valve disease. There are two main types of imaging used to test for these conditions. Coronary artery disease can be diagnosed by taking X-ray pictures of a dye when injected into the blood vessels. In some cases the dye is injected into the veins and a CT scanner is used (CT coronary angiography), in others the dye is injected via a tube placed in the artery (invasive coronary angiography). Valvular heart disease is normally diagnosed using an echocardiogram (ultrasound of the heart). In this study the investigators are looking for subtle changes in the sounds that come from the heart, which may allow heart disease to be detected earlier. The investigators are using a novel device, similar to a digital stethoscope, that has excellent sensitivity for heart sounds. Ultimately this may be used in community settings including GP surgeries, in this study the investigators are collecting sounds from patients undergoing routine scans as part of their workup for heart disease.

Key Dates

First listed
Mar 27, 2026
Start date
May 1, 2026
Status verified
Mar 2026
Primary completion
Dec 31, 2027
Completion
Dec 31, 2029

Study Design

Enrollment
500 participants (estimated)

Arms

  • Arm: Control
    No valvular heart disease, no coronary artery disease
  • Arm: Coronary artery disease
    Significant coronary artery disease, no valvular heart disease
  • Arm: Valvular heart disease
    Significant valvular heart disease, no coronary artery disease
  • Arm: Mixed disease
    Significant coronary artery disease and significant valvular heart disease

Primary Outcome Measure

Discriminant score [ Time Frame: Investigations to be performed within six (6) months of one another. ]

Central Contacts

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