Multimodal Nutritional and Sarcopenia Assessment for Risk Stratification in Lung Cancer Surgery

Sponsor
Ondokuz Mayıs University
Study ID
NCT07500376
Status
Recruiting
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Conditions

  • Lung Cancer (Non-Small Cell)
  • Malnutrition Severe
  • Sarcopenia

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Observational Assessment — OTHER
    Participants will undergo standard preoperative clinical evaluation including nutritional assessment, laboratory measurements, and imaging-based body composition analysis as part of routine care. No experimental intervention or treatment is administered. All data are collected observationally without influencing clinical management.

Study Details

This prospective observational cohort study aims to evaluate the prognostic value of multimodal nutritional status and sarcopenia assessment in patients undergoing lung cancer surgery. Postoperative complications, mortality, and prolonged hospital stay remain major clinical concerns in thoracic surgery. Although malnutrition and sarcopenia are recognized as important determinants of surgical outcomes, their combined and multidimensional evaluation has not been sufficiently studied. Adult patients undergoing anatomical lung resection for primary lung cancer will be included. Nutritional status will be assessed using serum biomarkers, inflammatory indices, and validated clinical nutritional scores. Sarcopenia will be evaluated using computed tomography-based muscle mass and density measurements, as well as ultrasonographic muscle thickness. These parameters will be analyzed in relation to postoperative complications, intensive care unit (ICU) requirement, length of hospital stay, and mortality. Multivariable analyses will be performed to identify independent predictors, and a combined risk stratification model will be developed. This study aims to improve preoperative risk assessment and to support personalized perioperative management strategies, including identification of patients who may benefit from targeted nutritional optimization and prehabilitation.

Key Dates

First listed
Mar 30, 2026
Start date
Mar 15, 2026
Status verified
Mar 2026
Primary completion
May 15, 2026
Completion
Jul 15, 2026

Study Design

Enrollment
142 participants (estimated)

Arms

  • Arm: Lung Cancer Surgery Cohort
    Adult patients undergoing anatomical lung resection (lobectomy or segmentectomy) for primary lung cancer will be prospectively enrolled. Preoperative nutritional status and sarcopenia will be assessed using biochemical markers, validated nutritional scores, and imaging-based muscle measurements. Patients will be followed for postoperative outcomes including complications, intensive care unit requirement, length of hospital stay, and mortality.

Primary Outcome Measure

Postoperative complications (30-day, Clavien-Dindo classification) [ Time Frame: Within 30 days after surgery ]

Central Contacts

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