Association Between Periodontitis and Chronic Kidney Disease

Sponsor
Yu Tang
Study ID
NCT07506590
Status
Not Yet Recruiting

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Conditions

  • Chronic Kidney Diseases
  • Periodontitis

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Study Details

The goal of this observational study is to explore the comorbid association between periodontitis and chronic kidney disease (CKD) based on the oral-renal axis in adults aged 18 to 75 years. The main question it aims to answer is: Is periodontitis associated with chronic kidney disease through oral-renal axis-related mechanisms? Participants aged 18 to 75 years will be recruited and undergo clinical assessment, sample collection, and laboratory testing as part of the study. Periodontal status, kidney function, and oral microbiota characteristics will be evaluated to investigate the association between periodontitis and CKD. Fecal samples will also be collected for exploratory analysis of gut microbiota to assess its potential relevance to the oral-renal relationship.

Key Dates

First listed
Apr 1, 2026
Start date
May 1, 2026
Status verified
Mar 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
80 participants (estimated)

Arms

  • Arm: PD(+)/CKD(-)
    Participants with periodontitis but without chronic kidney disease.
  • Arm: PD(+)/CKD(+)
    Participants with both periodontitis and chronic kidney disease.
  • Arm: PD(-)/CKD(+)
    Participants with chronic kidney disease but without periodontitis.
  • Arm: PD(-)/CKD(-)
    Healthy controls without periodontitis or chronic kidney disease.

Primary Outcome Measure

Oral microbiota composition [ Time Frame: At baseline ]

Central Contacts

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