Calciphylaxis in Patients With Chronic Kidney Disease - A Study of the Danish Calciphylaxis Research Initiative (DanCaRI)

Sponsor
Odense University Hospital
Study ID
NCT07511283
Status
Recruiting
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Conditions

  • Calcific Uremic Arteriolopathy
  • Calciphylaxis
  • Chronic Kidney Diseases
  • End Stage Renal Disease (ESRD)
  • Nephrogenic Calciphylaxis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Calciphylaxis is a rare yet life-threatening condition involving pronounced calcification in small blood vessels of the skin. Knowledge about its underlying mechanisms and contributing risk factors remains limited. Chronic kidney disease is one of the strongest disease predictors. No evidence based effective therapy is currently available. Research on the topic is mainly hindered by the condition's rarity. The study Calciphylaxis in patients with chronic kidney disease - A study of the Danish Calciphylaxis Research Initiative (DanCaRI) is set up to facilitate the systematic retrospective and prospective comparison of patients with chronic kidney disease and calciphylaxis to matched patients with chronic kidney disease who did not develop calciphylaxis thereby providing new knowledge that can support prevention, early detection, and new treatment approaches.

Key Dates

First listed
Apr 6, 2026
Start date
Apr 30, 2026
Status verified
Mar 2026
Primary completion
Jun 30, 2040
Completion
Jun 30, 2040

Study Design

Enrollment
860 participants (estimated)

Arms

  • Arm: Patients with chronic kidney disease diagnosed or suspected for calciphylaxis
  • Arm: Matched control patients with chronic kidney disease without calciphylaxis
  • Arm: Age matched healthy reference group

Primary Outcome Measure

All-cause mortality [ Time Frame: 3 year follow up period ]

Central Contacts

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