Load Incorporating Cardiac Assessment by Echocardiography In Patients With SEpsis (LIAISE Study)

Sponsor
The University of Queensland
Study ID
NCT07562217
Status
Not Yet Recruiting

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Conditions

  • Sepsis

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The LIAISE study is a prospective observational study comparing the performance of load-incorporating echocardiographic parameters and conventional parameters in predicting adverse events among adult patients presenting to the ICU with sepsis. It will be conducted in hospitals in Australia, Hong Kong, South Africa, and Canada, with 199 patients recruited over 2 years. All included patients will receive an regular echocardiographic assessment and their haemodynamic parameters will be simultaneously recorded. Participants will be followed for up to 1 year after enrolment. Load incorporating parameters will be derived from regularly obtained echocardiography and haemodynamic data during offline analysis. The predictive value of cardiac parameters will be evaluated based on their statistical association with clinical outcomes.

Key Dates

First listed
May 1, 2026
Start date
May 1, 2026
Status verified
Oct 2025
Primary completion
Dec 31, 2027
Completion
Nov 30, 2028

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Sepsis with hypotension or signs of hypoperfusion admitted to ICU

Primary Outcome Measure

All cause death [ Time Frame: Day 30 after ICU admission ]

Central Contacts

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