Diet and WB-EMS Effects in Obesity

Sponsor
Firat University
Study ID
NCT07562724
Status
Not Yet Recruiting

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Conditions

  • Electrotherapy
  • Metabolic Disorders
  • Obesity & Overweight

Eligibility Criteria

Sex
ALL
Age
18 Years - 65 Years
Healthy Volunteers
Not accepted

Interventions

  • Energy-Restricted Diet — BEHAVIORAL
    A personalized diet with approximately 750 kcal/day energy deficit.
  • Whole-Body Electromyostimulation (WB-EMS) — DEVICE
    Whole-body electromyostimulation applied 2-3 times per week for 8 weeks under supervision.

Study Details

Obesity is a major global health problem associated with metabolic dysfunction, altered adipokine signaling, and impaired appetite regulation. Conventional weight loss strategies such as calorie restriction often result in compensatory physiological adaptations, including increased appetite and loss of lean body mass, which may limit long-term effectiveness. Whole-body electromyostimulation (WB-EMS) is an emerging, time-efficient intervention that induces simultaneous muscle activation and may improve metabolic health. However, the underlying molecular mechanisms, particularly the interaction between myokines and adipokines, remain insufficiently understood. This randomized controlled trial aims to investigate the effects of an energy-restricted diet combined with WB-EMS on myokine-adipokine interaction, appetite regulation, and body composition in obese individuals. Participants will be randomly assigned to either a diet-only group or a diet plus WB-EMS group for 8 weeks. Primary outcomes include changes in serum irisin levels. Secondary outcomes include myostatin, leptin, adiponectin, FGF-21, ghrelin, GLP-1, body composition parameters, and eating behavior. The findings of this study are expected to provide novel insights into the physiological and molecular effects of WB-EMS as a complementary strategy in obesity management.

Key Dates

First listed
May 1, 2026
Start date
Sep 1, 2026
Status verified
May 2026
Primary completion
Jan 20, 2027
Completion
Jun 20, 2027

Study Design

Enrollment
40 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Diet Only
    Participants receive an individualized energy-restricted diet program.
  • Experimental: Diet + WB-EMS
    Participants receive an energy-restricted diet combined with whole-body electromyostimulation (WB-EMS).

Primary Outcome Measure

Change in serum irisin levels [ Time Frame: Baseline to 8 weeks ]

Central Contacts

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