Velocity-Based Resistance Training Effects on Inflammation in Older Adults

Sponsor
National Taipei University
Study ID
NCT07566832
Status
Recruiting
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Conditions

  • Aging
  • Inflammatory Response

Eligibility Criteria

Sex
ALL
Age
60 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • Resistance exercise — OTHER
    The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.

Study Details

This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults. Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group. Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase. The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.

Key Dates

First listed
May 5, 2026
Start date
Apr 20, 2026
Status verified
Apr 2026
Primary completion
Mar 31, 2029
Completion
Dec 31, 2029

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT

Arms

  • Experimental: low training volume resistance exercise
    Participants assigned to the low-volume resistance training group will perform one set per exercise at a load corresponding to 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% from the first repetition. Rest intervals of 2-3 minutes will be provided between exercises.
  • Experimental: medium training volume resistance exercise
    Participants assigned to the medium-volume resistance training group will perform three sets per exercise at 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% relative to the first repetition. Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.
  • Experimental: high training volume resistance exercise
    Participants assigned to the high-volume resistance training group will perform five sets per exercise at 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% relative to the first repetition. Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.
  • No Intervention: sedentary control
    Participants in control trial stayed sedentary during the period.

Primary Outcome Measure

Changes in IL-6 concentration [ Time Frame: Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining ]

Central Contacts

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