Explore the Impacts of Theta Burst Stimulation Over the Right Inferior Frontal Gyrus in Autism Spectrum Disorder: Combination of Clinical Symptoms, Neuropsychological Function and MRI

Sponsor
Chang Gung Memorial Hospital
Study ID
NCT07579494
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
8 Years - 30 Years
Healthy Volunteers
Not accepted

Interventions

  • intermittent theta burst stimulation — DEVICE
    stimulatory protocol

Study Details

Exploring the therapeutic efficacy of Theta Burst Stimulation (TBS) over the right inferior frontal gyrus (RIFG) in autism, including changes in core symptoms, adaptive functioning, neuropsychological performance, and neurophysiological signals.

Key Dates

First listed
May 12, 2026
Start date
May 5, 2026
Status verified
May 2026
Primary completion
Jul 31, 2030
Completion
Dec 31, 2030

Study Design

Enrollment
60 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Active
    Participants received the intervention of iTBS (The total pulse of every session is 600 pulses) over right inferior frontal gyrus for 4 weeks (5 days/week). \*iTBS = intermittent theta burst stimulation
  • Sham Comparator: Sham
    Participants received the sham intervention of iTBS (sham-coil) over right inferior frontal gyrus for 4 weeks (5 days/week).

Primary Outcome Measure

Changes of total scores of Social Responsiveness Scale [ Time Frame: baseline; post TBS (4 weeks after baseline); One month follow up (8 weeks after baseline); Two months follow up (12 weeks after baseline) ]

Central Contacts

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