Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients

Sponsor
Konya Meram State Hospital
Study ID
NCT07580144
Status
Recruiting
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Conditions

  • Frailty
  • Neuromuscular Blockade
  • Pharmacodynamics
  • Rocuronium
  • Sarcopenia

Eligibility Criteria

Sex
ALL
Age
65 Years - 80 Years
Healthy Volunteers
Not accepted

Study Details

This prospective observational study aims to evaluate whether sarcopenia and frailty affect the pharmacodynamic profile of rocuronium in geriatric patients undergoing elective surgery under general anesthesia.

Key Dates

First listed
May 12, 2026
Start date
May 13, 2026
Status verified
May 2026
Primary completion
Aug 1, 2026
Completion
Aug 5, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Group/Cohort 1-Frailty
    Presence of frailty based on the Fried frailty phenotype.
  • Arm: Group/Cohort 2-Sarcopenia
    Presence of sarcopenia based on preoperative clinical and ultrasonographic assessment.
  • Arm: Group/Cohort 3 - Frail and Sarcopenic Group
    Geriatric patients who meet the criteria for both frailty and sarcopenia.
  • Arm: Group/Cohort 4 - Control Group
    Geriatric patients who meet neither frailty nor sarcopenia criteria.

Primary Outcome Measure

Rocuronium onset time [ Time Frame: Perioperative/Periprocedural - during anesthesia induction ]

Central Contacts

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