China-NINE Cohort：Neuroimmune Network in Elderly / Neurodegeneration

Sponsor
Yantai Yuhuangding Hospital
Study ID
NCT07586501
Status
Enrolling By Invitation

Conditions

  • Cognitive Dysfunction
  • Cognitive Dysfunction, Cognitive Disorder
  • Parkinson's Disease (PD)

Eligibility Criteria

Sex
ALL
Age
55 Years - 75 Years
Healthy Volunteers
Accepted

Study Details

This is an observational study aimed at understanding the cognitive, functional, and behavioral characteristics of Chinese patients with cognitive impairment, exploring the underlying mechanisms, and providing evidence for early diagnosis, treatment, and care of cognitive disorders including dementia. Eligible participants will undergo a series of assessments and examinations, including cognitive and memory scale tests, routine blood tests, ApoE genetic testing, cerebrospinal fluid testing, brain MRI, functional MRI, and FDG-PET/AV45-PET scans when necessary. Additional samples such as saliva, nasal secretions, and stool may also be collected. Most evaluations are provided free of charge to support diagnosis and treatment guidance. Participation is voluntary. All personal information and research data will be kept confidential. Potential benefits include access to expert clinical care and free cognitive assessments for disease evaluation. Possible inconveniences include time commitment and temporary discomfort during examinations; medical support will be provided if needed.

Key Dates

First listed
May 14, 2026
Start date
Jan 16, 2026
Status verified
May 2026
Primary completion
Jan 1, 2029
Completion
Jan 1, 2029

Study Design

Enrollment
260 participants (estimated)

Primary Outcome Measure

Degree and Type of Cognitive Impairment Assessed by Neuropsychological Scales [ Time Frame: From enrollment to the end of treatment at 3 years ]

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