IO Vancomycin Administration in TKA

Part of paid clinical trials in San Diego, California.

Sponsor
University of California, San Diego
Study ID
NCT07633418
Phase
PHASE4
Status
Not Yet Recruiting

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Conditions

  • Total Knee Arthroplasty

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Intraosseous Vamcomycin Administration — DRUG
    IO Vancomycin Administration in TKA

Study Details

This is a prospective, single-center, open-label study evaluating systemic vancomycin levels following preoperative intraosseous administration in patients undergoing primary unilateral total knee arthroplasty. Eligible participants will receive preoperative intraosseous vancomycin (500 mg in 100 mL saline) as part of standard perioperative infection prophylaxis. The study is open-label due to the nature of the intervention. Blood samples will be collected at predefined time points intraoperatively to measure serum vancomycin concentrations. Patients will be randomized to either a tourniquet or no tourniquet for these blood draws.

Key Dates

Start date
Jun 1, 2026
Status verified
May 2026
Primary completion
Apr 29, 2027
Completion
Apr 29, 2029

Study Design

Enrollment
30 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Other: Non tourniquet IO Vancomycin
    TKA IO Vancomycin administration with no tourniquet.
  • Other: Tourniquet IO Vancomycin
    TKA IO Vancomycin Administration with tourniquet

Primary Outcome Measure

Serum Vancomycin Levels [ Time Frame: From administration up to 30 minutes post-administration. ]

Central Contacts

Locations (1)

FacilityCityStateZIP
UC San DiegoSan DiegoCalifornia92093

Find similar trials in San Diego, CA

By research site
UC San Diego· San Diego, CA

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