Intravenous Metoclopramide Versus Intravenous Acetaminophen for Acute Concussion Treatment

Conditions

• Concussion Post Syndrome
• Head Trauma Injury

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Interventions

• Metoclopramide 10mg — DRUG
  Intravenous drip
• Acetaminophen — DRUG
  Intravenous drip over 15 minutes

Study Details

The IMPACT study is a randomized, double-blind clinical trial evaluating two commonly used intravenous medications - metoclopramide and acetaminophen - for treating acute post-concussion symptoms in emergency department patients after mild head injury. The study aims to determine which treatment more effectively improves symptoms such as headache, dizziness, nausea, concentration difficulties, and emotional changes within the first week after injury. Participants will be enrolled across two Montefiore emergency departments and followed using a validated post-concussion symptom questionnaire. Findings from this study may help improve evidence-based treatment strategies for patients experiencing concussion-related symptoms after head trauma.

Key Dates

Start date

Aug 1, 2026

Status verified

Jun 2026

Primary completion

Jun 30, 2028

Completion

Aug 4, 2028

Study Design

Enrollment

200 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Active Comparator: Metoclopramide 10 mg
  Metoclopramide 10 mg IV over 15 minutes
• Active Comparator: Acetaminophen
  1000 Mg IV over 15 minutes

Primary Outcome Measure

Change in Rivermead Post-Concussion Symptoms Questionnaire (RPQ) score [ Time Frame: From baseline to 48 hours post-treatment ]

Central Contacts

• Hamed Sarikhani, MD
  929-731-2137
  [email protected]
• Benjamin W W.Friedman, MD,MS
  7189043333
  [email protected]

Locations (1)

Find similar trials in New York, NY

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